A comprehensive prospective study tracking over 159,000 adults for up to three decades has provided compelling evidence that multiple healthy dietary patterns protect cognitive function, with the DASH diet demonstrating the most powerful effects. Researchers simultaneously evaluated six dietary approaches—including the Mediterranean-style AHEI-2010, plant-based hPDI, environmentally-focused PHDI, and diets targeting […]
A comprehensive new Cochrane review of 22 studies involving nearly 2,000 participants over six months to one year has found that intermittent fasting may offer little to no significant benefit over standard dietary advice for weight loss in people with overweight or obesity. When compared to regular, calorie-restricted diet plans, […]
A large-scale study involving 103,649 UK Biobank participants has revealed that adhering to healthy dietary patterns is significantly associated with lower mortality rates and a longer lifespan. Over a median follow-up of 10.6 years, researchers found that five specific diets—the Alternate Healthy Eating Index-2010, Alternate Mediterranean Diet (AMED), healthful Plant-based […]
To address uncertainties in statin safety profiles, which are often based on observational data susceptible to bias, researchers conducted a definitive meta-analysis of individual participant data from major double-blind, randomized controlled trials. The study first identified all undesirable effects listed in the official Summaries of Product Characteristics (SmPCs) for five […]
In a Chinese phase 3 trial (LungTIME-C01) involving 210 patients with advanced non-small cell lung cancer, administering anti-PD-1 immunotherapy before 3:00 PM nearly doubled progression-free survival (11.3 vs. 5.7 months) and significantly improved overall survival (28.0 vs. 16.8 months) compared to later infusions. This early time-of-day treatment was linked to […]
Recent US stroke guidelines incorporate significant advances across the care continuum. Mobile Stroke Units (MSUs) are now recommended for their ability to accelerate thrombolysis. For suspected large vessel occlusion, bypassing to an endovascular thrombectomy (EVT)-capable center is endorsed when efficient. Intravenous thrombolysis (IVT) guidelines now include tenecteplase as non-inferior to […]
A systematic review and meta-analysis of 27 observational studies, encompassing over 74,000 participants from 7 countries, indicates that consuming water with higher salinity is associated with increased blood pressure and hypertension risk. The analysis found that higher drinking water salinity was linked to average increases of 3.22 mm Hg in […]
A large natural experiment study in Ontario, Canada, found that receiving the live attenuated herpes zoster vaccine significantly reduced the risk of a new dementia diagnosis by approximately 18% in adults aged 70 and older, providing the strongest evidence to date for a potential causal protective effect. The research leveraged […]
According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 […]
Released in early 2026, the latest U.S. Dietary Guidelines champion a “real food” approach, advising Americans to prioritize whole foods like vegetables, fruits, proteins, and healthy fats while sharply limiting ultra-processed items, added sugars, and artificial additives. This update introduces significant shifts, including a higher daily protein recommendation, a move […]