A new clinical practice guideline from the American Academy of Sleep Medicine indicates that cognitive behavioral therapy for insomnia (CBT-I) alone remains the most effective first-line treatment for chronic insomnia, while adding medication may offer modest benefits for select outcomes such as total sleep time. The guideline is supported by […]
While myocardial infarction (MI) accounts for a substantial proportion of sudden cardiac deaths (SCDs), most arrhythmic SCDs occur in individuals without previously diagnosed risk factors, often due to occult cardiac disease such as silent MI or dilated cardiomyopathy. In the 12-year US countywide POST SCD autopsy study, 943 presumed sudden […]
In patients with prior intracerebral hemorrhage, adding a single pill combining three low-dose antihypertensive agents to standard care significantly reduced recurrent stroke and major cardiovascular events compared with placebo. In this multinational, double-blind, randomized controlled trial of 1,670 clinically stable patients with baseline systolic blood pressure (BP) of 130–160 mm […]
In older adults, longer and more frequent daytime naps, particularly those occurring in the morning, were associated with a higher risk of all-cause mortality based on objective actigraphy measurements. In this prospective cohort study from the US Rush Memory and Aging Project, 1,338 community-dwelling adults (mean age 81.4 years, 76% […]
Anemia was associated with higher levels of Alzheimer disease (AD) blood biomarkers and a markedly increased long-term risk of dementia, with the highest risk observed when low hemoglobin coexisted with elevated neurodegenerative markers. In a population-based cohort from the Swedish National Study on Aging and Care in Kungsholmen, 2,282 dementia-free […]
Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
In patients with established cardiovascular disease (CVD), calcium supplementation was associated with an increased risk of recurrent CVD events and related hospitalizations, particularly with calcium-only use and among men. In this large retrospective population-based study from Hong Kong, 17,720 matched patients receiving calcium supplements were compared with an equal number […]
Recent recommendations of US guidelines highlight the importance of treating dyslipidemia earlier in life, refining cardiovascular risk assessment, and adopting lower LDL cholesterol targets to reduce long-term exposure to atherogenic lipoproteins and prevent atherosclerotic cardiovascular disease (ASCVD). Lifestyle counseling should begin in youth, with early pharmacologic therapy considered for individuals […]
In high-risk patients with diabetes but no known significant atherosclerosis, treatment with evolocumab significantly reduced the risk of a first major cardiovascular event compared with placebo when added to statin therapy. This prespecified subgroup analysis of the VESALIUS-CV randomized, double-blind, placebo-controlled trial included 3,655 participants from 774 sites across 33 […]
A prospective US study suggests that greater adherence to the Mediterranean–Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet was associated with slower structural brain aging, including reduced gray matter loss and slower enlargement of brain ventricles over time. In the analysis of 1,647 middle-aged and older […]