The US updated evidence-based recommendations provide clinicians with comprehensive guidance on when to initiate pharmacologic migraine prevention, how to select an appropriate preventive medication, and how to monitor treatment effectiveness, adverse effects, and medication discontinuation in adults. Developed by a multidisciplinary panel using a systematic review of studies published through […]
In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse compared with anticoagulation alone, without a significant increase in clinically relevant or major bleeding. In this Czech multicenter, open-label, randomized trial, 558 […]
In a large randomized trial, atorvastatin 40 mg daily significantly reduced major cardiovascular events by 30% among community-dwelling adults aged 70 years or older without prior cardiovascular disease, diabetes, or dementia, but it did not significantly prolong disability-free survival over a median follow-up of 5.9 years. The double-blind, placebo-controlled trial […]
In patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), aficamten significantly improved exercise capacity and patient-reported health status compared with placebo at 36 weeks. In this phase 3 multinational, double-blind trial, 517 adults were randomly assigned to receive aficamten or placebo for up to 72 weeks. At week 36, the Kansas […]
In patients with atrial fibrillation at intermediate risk for stroke, direct oral anticoagulant (DOAC) therapy significantly reduced the 24-month risk of a composite of stroke, systemic embolism, major bleeding, or cardiovascular death compared with no anticoagulation. In the Korean multicenter, open-label, adjudicator-masked randomized trial, 1,803 patients with a CHA₂DS₂-VASc score […]
The recombinant shingles vaccine was associated with a 9% reduction in overall cardiovascular burden over 7 years among adults aged 60 years or older, based on a natural experiment that reduced confounding from existing studies comparing vaccinated and unvaccinated individuals. Researchers compared adults vaccinated immediately before versus immediately after the […]
In a US retrospective observational cohort study of 623 young adults, significant infradian (multiday) heart rate rhythms were detected in 70% of participants, with 36% showing two or more distinct rhythms. Using up to four years of wearable and questionnaire data from the University of Notre Dame’s NetHealth project, researchers […]
Early-life sugar restriction during pregnancy and infancy was associated with a 34% lower risk of early-onset cancer (diagnosed by age 50), although it was not associated with a significant reduction in cancer-specific mortality. Using a natural experiment created by the end of UK sugar rationing, researchers analyzed 63,819 UK Biobank […]
Higher levels of physical activity were associated with lower risks of all-cause dementia, Alzheimer’s disease, and vascular dementia, but the associations differed substantially by physical activity domain. In this systematic review and meta-analysis, 74 cohort and case–control studies involving 4,227,297 participants were analyzed, with a median follow-up of 10.0 years. […]
In US adults aged ≥65 years, overweight and class I–II obesity were associated with lower all-cause mortality risk, whereas high waist circumference and being underweight were associated with higher mortality risk, highlighting the importance of central adiposity and the limitations of BMI alone for mortality risk stratification. Using 14 years […]