Anemia was associated with higher levels of Alzheimer disease (AD) blood biomarkers and a markedly increased long-term risk of dementia, with the highest risk observed when low hemoglobin coexisted with elevated neurodegenerative markers. In a population-based cohort from the Swedish National Study on Aging and Care in Kungsholmen, 2,282 dementia-free […]
Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
In patients with established cardiovascular disease (CVD), calcium supplementation was associated with an increased risk of recurrent CVD events and related hospitalizations, particularly with calcium-only use and among men. In this large retrospective population-based study from Hong Kong, 17,720 matched patients receiving calcium supplements were compared with an equal number […]
Recent recommendations of US guidelines highlight the importance of treating dyslipidemia earlier in life, refining cardiovascular risk assessment, and adopting lower LDL cholesterol targets to reduce long-term exposure to atherogenic lipoproteins and prevent atherosclerotic cardiovascular disease (ASCVD). Lifestyle counseling should begin in youth, with early pharmacologic therapy considered for individuals […]
In high-risk patients with diabetes but no known significant atherosclerosis, treatment with evolocumab significantly reduced the risk of a first major cardiovascular event compared with placebo when added to statin therapy. This prespecified subgroup analysis of the VESALIUS-CV randomized, double-blind, placebo-controlled trial included 3,655 participants from 774 sites across 33 […]
A prospective US study suggests that greater adherence to the Mediterranean–Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet was associated with slower structural brain aging, including reduced gray matter loss and slower enlargement of brain ventricles over time. In the analysis of 1,647 middle-aged and older […]
A prospective US cohort study leveraging data from 3,477 participants (mean age 74.8 years; 61.5% female) in the Atherosclerosis Risk in Communities (ARIC) study has found that higher aldosterone-renin ratio (ARR) is independently associated with increased cardiovascular risk over nearly a decade of follow-up. Researchers measured serum aldosterone and renin […]
A recent study suggests that daily multivitamin-mineral supplements could slightly slow the biological aging process in older adults, though the effect size is modest and requires further investigation. As part of the COSMOS trial, researchers analyzed data from 958 participants over two years using advanced “epigenetic clocks”—DNA methylation measures that […]
A rigorous cohort study utilizing Taiwan’s National Health Insurance Database provides robust evidence that SGLT2 inhibitors offer superior multi-organ protection for the complex population of patients with both type 2 diabetes and liver cirrhosis. Among 24,259 adults (average age 64.7 years; 33.9% female) followed for a median of 2.3 years, […]
A new study investigating the link between cerebral microbleeds (CMBs) and dementia has found that the location and pattern of these brain lesions are critical to assessing risk. Analyzing data from over 1,500 participants in the ARIC-Neurocognitive Study, researchers classified individuals based on their CMB patterns—lobar, subcortical, or mixed—and tracked […]