Effects of Sacubitril/Valsartan Compared With ARBs or CCBs

A meta-analysis of 15 randomized controlled trials involving 4,824 patients with high blood pressure found that sacubitril/valsartan significantly improved multiple ambulatory blood pressure measures compared with angiotensin receptor blockers (ARBs) or calcium channel blockers (CCBs), with a favorable safety profile. Compared with ARBs or CCBs, sacubitril/valsartan reduced 24-hour systolic and […]

Chronic Inflammation: A Common Pathway Linking Genetic and Environmental Cardiovascular Risk

Higher levels of chronic systemic inflammation were associated with smaller left ventricular volumes, compensatory increases in heart rate, and substantially higher cardiovascular risk in a large UK Biobank study. Among 488,079 participants with metabolomic, proteomic, cardiac MRI, and longitudinal data, higher inflammation measured by glycoprotein acetyls (GlycA) was associated with […]

Carotid Revascularization Does Not Improve Cognition in Asymptomatic Severe Carotid Stenosis

In patients with severe asymptomatic carotid artery stenosis, carotid revascularization—either carotid artery stenting (CAS) or carotid endarterectomy (CEA)—added to intensive medical management (IMM) did not significantly improve cognitive function compared with IMM alone over up to 4 years. The CREST-2 randomized clinical trials included 2,366 US patients, of whom 2,165 […]

Exercise-Based Cardiac Rehabilitation Improves Outcomes in Coronary Heart Disease

A 2026 Cochrane systematic review and meta-analysis of 107 randomized trials involving 26,886 adults with coronary heart disease (CHD) found that exercise-based cardiac rehabilitation (CR), compared with no structured exercise, reduces myocardial infarction (MI) and all-cause hospitalizations, likely provides a small reduction in mortality, and improves health-related quality of life […]

Early Brain Ageing Linked to the Gut–Brain Axis

Higher functional-connectivity-derived brain age deviation was consistently associated with poorer cognitive performance—particularly working memory and executive function—and greater depressive symptoms in young and mid-life adults, while also showing links to gut microbial and metabolic signatures. In a discovery cohort of 674 participants, with replication in a cohort of 444 and […]

Nighttime Light Exposure Linked to Higher Cardiovascular Risk

Higher nighttime light exposure was associated with adverse changes in cardiac structure and function and increased risks of cardiovascular disease (CVD) events and death. In this UK Biobank population-based study, 11,071 participants with 7-day wrist-worn light measurements and subsequent cardiac MRI were evaluated, with high nighttime light exposure (>3 lux) […]

Hot Drinks Linked to Esophageal Squamous Cell Carcinoma Risk

In two UK cohorts including 977,282 adults, drinking beverages at a “very hot” temperature was associated with more than a threefold higher risk of esophageal squamous cell carcinoma (SCC), while drinking 6 or more hot beverages per day was associated with a 71% higher SCC risk. Over 11–14 years of […]

Hemoglobin Levels and Mortality

In a UK prospective cohort of 502,188 adults followed for a median of 13.6 years, mortality was lowest at hemoglobin concentrations approximately 1–3 g/dL above the current WHO anemia thresholds, while both lower and higher concentrations were associated with increased mortality. The association between hemoglobin and all-cause mortality was U-shaped: […]

Exhaled Carbon Monoxide Linked to Lower Parkinson Disease Risk

Regular smoking was associated with a lower risk of Parkinson disease (PD), and among people who never smoked, higher levels of exhaled carbon monoxide (CO) were associated with a lower risk of PD in a broadly dose-dependent manner. This nationwide prospective cohort study included 512,724 adults aged 30–79 years from […]

Alcohol-Attributable Cancer Mortality Doubled in the USA Since 1990

Alcohol-attributable cancer deaths in the USA doubled from 11,361 in 1990 to 23,126 in 2023, with a disproportionate burden among men and adults aged 55 years and older. This population-based observational trend analysis used Global Burden of Disease data to examine age-standardized mortality rates (ASMRs) attributable to heavy alcohol use […]