Function-Guided Complete Revascularization Improves Outcomes in STEMI

In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease, complete coronary revascularization guided by functional coronary angiography significantly reduced both major cardiovascular events and key safety events compared with conventional angiography-guided treatment. In this international randomized trial, 1,823 patients whose culprit lesion had been successfully treated […]

2026 Fifth Universal Definition of Myocardial Infarction

The Fifth Universal Definition of Myocardial Infarction (MI) updates the classification of MI by defining three major clinical settings—primary MI, secondary MI, and procedure-related MI—to better reflect underlying pathophysiology, support clinical evaluation, and incorporate objective diagnostic criteria. Primary MI occurs spontaneously because of an acute coronary pathology; although most cases […]

Updated US Guideline on Pharmacologic Prevention of Migraine in Adults

The US updated evidence-based recommendations provide clinicians with comprehensive guidance on when to initiate pharmacologic migraine prevention, how to select an appropriate preventive medication, and how to monitor treatment effectiveness, adverse effects, and medication discontinuation in adults. Developed by a multidisciplinary panel using a systematic review of studies published through […]

Catheter-Directed Thrombolysis Improves Outcomes in Intermediate-High–Risk Pulmonary Embolism

In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse compared with anticoagulation alone, without a significant increase in clinically relevant or major bleeding. In this Czech multicenter, open-label, randomized trial, 558 […]

Atorvastatin Prevents Cardiovascular Events in Older Adults without Prior Cardiovascular Disease

In a large randomized trial, atorvastatin 40 mg daily significantly reduced major cardiovascular events by 30% among community-dwelling adults aged 70 years or older without prior cardiovascular disease, diabetes, or dementia, but it did not significantly prolong disability-free survival over a median follow-up of 5.9 years. The double-blind, placebo-controlled trial […]

Aficamten Improves Exercise Capacity and Health Status in Nonobstructive HCM

In patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), aficamten significantly improved exercise capacity and patient-reported health status compared with placebo at 36 weeks. In this phase 3 multinational, double-blind trial, 517 adults were randomly assigned to receive aficamten or placebo for up to 72 weeks. At week 36, the Kansas […]

DOACs Reduce Cardiovascular Events in Atrial Fibrillation at Intermediate Stroke Risk

In patients with atrial fibrillation at intermediate risk for stroke, direct oral anticoagulant (DOAC) therapy significantly reduced the 24-month risk of a composite of stroke, systemic embolism, major bleeding, or cardiovascular death compared with no anticoagulation. In the Korean multicenter, open-label, adjudicator-masked randomized trial, 1,803 patients with a CHA₂DS₂-VASc score […]

Recombinant Shingles Vaccine Linked to Reduced Cardiovascular Risk

The recombinant shingles vaccine was associated with a 9% reduction in overall cardiovascular burden over 7 years among adults aged 60 years or older, based on a natural experiment that reduced confounding from existing studies comparing vaccinated and unvaccinated individuals. Researchers compared adults vaccinated immediately before versus immediately after the […]

Multiday Heart Rate Rhythms Common in Young Adults

In a US retrospective observational cohort study of 623 young adults, significant infradian (multiday) heart rate rhythms were detected in 70% of participants, with 36% showing two or more distinct rhythms. Using up to four years of wearable and questionnaire data from the University of Notre Dame’s NetHealth project, researchers […]

Early-Life Sugar Restriction Linked to Lower Risk of Early-Onset Cancer

Early-life sugar restriction during pregnancy and infancy was associated with a 34% lower risk of early-onset cancer (diagnosed by age 50), although it was not associated with a significant reduction in cancer-specific mortality. Using a natural experiment created by the end of UK sugar rationing, researchers analyzed 63,819 UK Biobank […]