Calcium and Vitamin D Supplements Provide Little Overall Protection Against Fractures and Falls

A comprehensive systematic review and meta-analysis involving 69 randomized controlled trials and 153,902 adults found that calcium supplements, vitamin D supplements, or their combination offer little to no clinically meaningful benefit in preventing fractures or falls in adults not taking osteoporosis medications. Most participants were community-dwelling individuals (87%) and were […]

Pulsed Field Ablation Proven Superior to Sham Procedure for Symptomatic AF

A sham-controlled randomized trial demonstrated that pulsed field ablation (PFA) markedly reduced atrial fibrillation (AF) recurrence and burden while significantly improving quality of life and psychological distress compared with a sham procedure in highly symptomatic AF patients. In this single-blind study, 60 patients with severe AF-related quality-of-life impairment were randomized […]

Preservative Food Additives Linked to Higher CVD Risks

A French prospective cohort study found that higher exposure to preservative food additives commonly used in industrial foods was associated with increased risks of high blood pressure and cardiovascular disease (CVD). Researchers analyzed data from 112,395 adults in the NutriNet-Santé cohort with a median follow-up of 7.9 years, using repeated […]

Coronary Microvascular Dysfunction Signals Higher Cardiovascular Risk

Coronary microvascular dysfunction (CMD) was common in patients undergoing invasive coronary angiography and was associated with nearly double the risk of major cardiovascular events. In this prospective multicenter study from South Korea involving 1,003 patients with suspected ischemic heart disease, CMD was identified in 21.5% of patients with obstructive epicardial […]

Daily Stress and IBS Symptoms Closely Influence Each Other Throughout the Day

A US prospective real-world study of 357 adults with Irritable Bowel Syndrome (IBS) found that higher daily stress levels were strongly associated with worse IBS symptom severity, and stress and symptoms appeared to reinforce each other especially from the afternoon into the evening. Researchers followed adults meeting Rome IV criteria […]

Omega-3 Supplements Linked to Faster Cognitive Decline in Older Adults

A longitudinal study using data from the Alzheimer’s Disease Neuroimaging Initiative found that omega-3 fatty acid supplementation was associated with accelerated cognitive decline in older adults, challenging the common belief that omega-3 universally protects brain health. Participants taking omega-3 supplements showed faster worsening in MMSE, ADAS-Cog13, and CDR-SB scores over […]

Accelerometer-Based Sleep-Wake Patterns May Help Predict Dementia Risk

Accelerometer-derived sleep-wake cycle patterns were associated with a higher risk of future dementia and modestly improved dementia prediction beyond traditional risk factors, with predictive value comparable to APOE genotype when added to an age-only model. In this large prospective cohort study involving more than 53,000 older adults from the UK […]

SGLT2 Inhibitor Use After Takotsubo Syndrome Linked to Lower Mortality

Early initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors after Takotsubo syndrome was associated with significantly lower all-cause mortality in a large real-world U.S. study, although reductions in cardiovascular complications were not observed. Using the TriNetX U.S. Collaborative Network, researchers identified adults diagnosed with Takotsubo syndrome between 2015 and 2025 and compared […]

Pros and Cons of PSA Screening for Prostate Cancer

An updated Cochrane systematic review of five randomized controlled trials involving 341,342 men found that PSA-based prostate cancer screening did not significantly reduce prostate cancer-specific mortality or overall mortality when all studies were combined, although one major European study (ERSPC) showed a 21% reduction in prostate cancer deaths among men […]

Egg Consumption Linked to Lower Alzheimer’s Risk

A US prospective study found that moderate egg consumption was associated with a significantly lower risk of Alzheimer’s disease, with participants eating eggs ≥5 times per week showing a 27% lower risk compared with those who rarely or never ate eggs. Researchers analyzed data from 39,498 participants in the Adventist […]