Hyperglycosylation Maybe a Key Driver of Alzheimer’s Disease Progression

A new study identifies brain hyperglycosylation—an excessive buildup of sugar-containing glycans on proteins—as a pathological driver of Alzheimer’s disease (AD), revealing a promising new target for treatment. By integrating spatial metabolomics, lipidomics, glycomics, and advanced isotopic tracing techniques in transgenic AD mouse models and post-mortem human brain samples, researchers found […]


2026 Key Recommendations for Preventing and Managing Cardiovascular-Kidney-Metabolic Syndrome

Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]


Low Lipoprotein(a) Levels Linked to Higher Diabetes Risk

An analysis from the FOURIER trial found that among patients with established atherosclerotic cardiovascular disease, lower lipoprotein(a) [Lp(a)] concentrations were associated with a higher prevalence of diabetes at baseline and a greater risk of developing diabetes during follow-up, while showing no increased risk of most other major adverse safety outcomes. […]


Even “Moderate” Drinking Raises Lifetime Health Risks

Even alcohol consumption commonly considered “moderate” was associated with increased lifetime risks of death and disease, with no evidence of a net protective health effect at low levels of drinking. Researchers estimated alcohol-attributable mortality and morbidity risks in the US by integrating data from national health surveys, U.S. Census population […]


Higher Ultraprocessed Food Intake Linked to Increased Dementia Risk

A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]


Visceral Fat Loss Linked to Lasting Cardiometabolic Benefits Despite Weight Regain

Long-term follow-up of two randomized lifestyle intervention trials found that reducing visceral fat—not simply losing weight—was strongly associated with sustained cardiometabolic health benefits, and every 10% reduction in visceral fat lowered the future risk of type 2 diabetes by 28%. Researchers followed 366 participants from the 18-month CENTRAL and DIRECT-PLUS […]


A Coordinated Sleep Rhythm May Reduce Dementia Risk

Recently identified brain rhythm during sleep may play a crucial role in clearing neurotoxic waste and protecting against dementia. Unlike wakefulness, when major neuromodulators such as norepinephrine, acetylcholine, serotonin, and dopamine act relatively independently, sleep synchronizes their activity into coordinated oscillations occurring approximately every 50 seconds. These rhythmic fluctuations are […]


Alzheimer’s Blood Biomarkers in Midlife

A US community-based study found that middle-aged adults with blood biomarkers indicating Alzheimer’s disease neuropathology already showed worse cognition and faster cognitive decline years before dementia diagnosis. Researchers analyzed 1,350 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent plasma biomarker testing at year 35 […]


Single-Dose Psilocybin Effective in Major Depression

A randomized clinical trial found that a single 25 mg dose of psilocybin produced rapid antidepressant effects in patients with moderate to severe recurrent major depressive disorder (MDD), with benefits emerging by day 2 and persisting for more than 3 months on several secondary measures. Conducted at the Northern Stockholm […]


ACS Updated Colorectal Cancer Screening Guidance

The American Cancer Society (ACS) reaffirmed that average-risk adults should begin colorectal cancer (CRC) screening at age 45 and continue through age 75 if life expectancy exceeds 10 years, while emphasizing that stool-based screening tests remain the preferred noncolonoscopy options over newer blood-based tests. CRC remains a leading cause of […]