Omega-3 Supplements Linked to Faster Cognitive Decline in Older Adults

A longitudinal study using data from the Alzheimer’s Disease Neuroimaging Initiative found that omega-3 fatty acid supplementation was associated with accelerated cognitive decline in older adults, challenging the common belief that omega-3 universally protects brain health. Participants taking omega-3 supplements showed faster worsening in MMSE, ADAS-Cog13, and CDR-SB scores over […]

Accelerometer-Based Sleep-Wake Patterns May Help Predict Dementia Risk

Accelerometer-derived sleep-wake cycle patterns were associated with a higher risk of future dementia and modestly improved dementia prediction beyond traditional risk factors, with predictive value comparable to APOE genotype when added to an age-only model. In this large prospective cohort study involving more than 53,000 older adults from the UK […]

SGLT2 Inhibitor Use After Takotsubo Syndrome Linked to Lower Mortality

Early initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors after Takotsubo syndrome was associated with significantly lower all-cause mortality in a large real-world U.S. study, although reductions in cardiovascular complications were not observed. Using the TriNetX U.S. Collaborative Network, researchers identified adults diagnosed with Takotsubo syndrome between 2015 and 2025 and compared […]

Pros and Cons of PSA Screening for Prostate Cancer

An updated Cochrane systematic review of five randomized controlled trials involving 341,342 men found that PSA-based prostate cancer screening did not significantly reduce prostate cancer-specific mortality or overall mortality when all studies were combined, although one major European study (ERSPC) showed a 21% reduction in prostate cancer deaths among men […]

Egg Consumption Linked to Lower Alzheimer’s Risk

A US prospective study found that moderate egg consumption was associated with a significantly lower risk of Alzheimer’s disease, with participants eating eggs ≥5 times per week showing a 27% lower risk compared with those who rarely or never ate eggs. Researchers analyzed data from 39,498 participants in the Adventist […]

Primary Care Approaches to Anxiety: CBT and SSRIs/SNRIs Lead Effective Treatment

Anxiety disorders are common yet often underrecognized in primary care, but a review shows that cognitive-behavioral therapy (CBT), selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs/SNRIs), and collaborative care models can substantially improve outcomes. Current recommendations support anxiety screening for adults younger than 65 years, with assessment including symptom questionnaires, clinical […]

Recombinant Zoster Vaccination Linked to Reduced Risk of Dementia in Older Adults

Two-dose recombinant zoster vaccination (RZV) was associated with a significantly lower risk of new-onset dementia, including Alzheimer’s disease (AD) and vascular dementia (VD), among U.S. adults aged 65 years or older. In this Medicare-based study, individuals who received RZV were matched to unvaccinated counterparts by age, sex, and race/ethnicity, all […]

Colonoscopy Screening Reduced Colorectal Cancer Incidence but No Significant Mortality Benefit

A 13-year follow-up of a randomized controlled trial found that a single colonoscopy screening significantly reduced colorectal cancer incidence but did not significantly lower mortality. In this multicountry study involving 84,583 adults aged 55–64 years from Norway, Poland, and Sweden, participants were randomized to receive colonoscopy screening or no screening. […]

Ultra-Processed Food Intake Linked to Poorer Attention and Higher Dementia Risk

Higher consumption of ultra-processed foods (UPFs) is associated with poorer attention and increased modifiable dementia risk, independent of overall diet quality. In this cross-sectional study of 2,192 dementia-free Australian adults aged 40–70 years, dietary intake was assessed using a validated food frequency questionnaire and categorized by the Nova classification system, […]

BP-Lowering Reduces Cardiovascular Risk Across All CKD Stages, with Attenuated Benefit in Diabetes

Blood pressure (BP)-lowering treatment significantly reduces the risk of major cardiovascular events in individuals with chronic kidney disease (CKD) across all stages, with effects comparable to those without CKD, although benefits are diminished in patients with coexisting diabetes. This one-stage individual-participant meta-analysis included 52 randomized controlled trials, of which 46 […]