Sugar-Sweetened Beverages Linked to Higher Risk of Liver Cancer Subtypes

A pooled analysis of 11 prospective cohort studies involving more than 1.5 million adults found that higher consumption of sugar-sweetened beverages (SSBs) was associated with an increased risk of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), whereas artificially sweetened beverages (ASBs) were not associated with liver cancer risk. Researchers […]


Vitamin K2 (MK-7) May Slow Coronary Artery Calcification Progression

A Dutch randomized clinical trial found that two years of vitamin K2 (menaquinone-7, MK-7) supplementation significantly slowed the progression of coronary artery calcification (CAC) in patients with symptomatic coronary artery disease (CAD) compared with placebo. In the VitaK-CAC study, 180 patients with existing coronary calcification were randomized to receive either […]


Rising ADHD and Autism Diagnoses May Reflect Broader Diagnostic Criteria

A Danish population-based cohort study found that individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) in more recent years carried lower average genetic risk scores for these conditions and related psychiatric traits than those diagnosed earlier, suggesting that the rising prevalence of ADHD and ASD is more […]


Hyperglycosylation Maybe a Key Driver of Alzheimer’s Disease Progression

A new study identifies brain hyperglycosylation—an excessive buildup of sugar-containing glycans on proteins—as a pathological driver of Alzheimer’s disease (AD), revealing a promising new target for treatment. By integrating spatial metabolomics, lipidomics, glycomics, and advanced isotopic tracing techniques in transgenic AD mouse models and post-mortem human brain samples, researchers found […]


2026 Key Recommendations for Preventing and Managing Cardiovascular-Kidney-Metabolic Syndrome

Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]


Low Lipoprotein(a) Levels Linked to Higher Diabetes Risk

An analysis from the FOURIER trial found that among patients with established atherosclerotic cardiovascular disease, lower lipoprotein(a) [Lp(a)] concentrations were associated with a higher prevalence of diabetes at baseline and a greater risk of developing diabetes during follow-up, while showing no increased risk of most other major adverse safety outcomes. […]


Even “Moderate” Drinking Raises Lifetime Health Risks

Even alcohol consumption commonly considered “moderate” was associated with increased lifetime risks of death and disease, with no evidence of a net protective health effect at low levels of drinking. Researchers estimated alcohol-attributable mortality and morbidity risks in the US by integrating data from national health surveys, U.S. Census population […]


Higher Ultraprocessed Food Intake Linked to Increased Dementia Risk

A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]


Visceral Fat Loss Linked to Lasting Cardiometabolic Benefits Despite Weight Regain

Long-term follow-up of two randomized lifestyle intervention trials found that reducing visceral fat—not simply losing weight—was strongly associated with sustained cardiometabolic health benefits, and every 10% reduction in visceral fat lowered the future risk of type 2 diabetes by 28%. Researchers followed 366 participants from the 18-month CENTRAL and DIRECT-PLUS […]


A Coordinated Sleep Rhythm May Reduce Dementia Risk

Recently identified brain rhythm during sleep may play a crucial role in clearing neurotoxic waste and protecting against dementia. Unlike wakefulness, when major neuromodulators such as norepinephrine, acetylcholine, serotonin, and dopamine act relatively independently, sleep synchronizes their activity into coordinated oscillations occurring approximately every 50 seconds. These rhythmic fluctuations are […]