Efficacy

Catheter-Directed Thrombolysis Improves Outcomes in Intermediate-High–Risk Pulmonary Embolism

This entry was posted in Cardiovascular Diseases and tagged Catheter-Directed Thrombolysis Efficacy Pulmonary Embolism Safety on

In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse compared with anticoagulation alone, without a significant increase in clinically relevant or major bleeding. In this Czech multicenter, open-label, randomized trial, 558 […]

Atorvastatin Prevents Cardiovascular Events in Older Adults without Prior Cardiovascular Disease

This entry was posted in Cardiovascular Diseases and tagged Adverse Effects CVD Efficacy Old Adults Primary Prevention Statins on

In a large randomized trial, atorvastatin 40 mg daily significantly reduced major cardiovascular events by 30% among community-dwelling adults aged 70 years or older without prior cardiovascular disease, diabetes, or dementia, but it did not significantly prolong disability-free survival over a median follow-up of 5.9 years. The double-blind, placebo-controlled trial […]

Aficamten Improves Exercise Capacity and Health Status in Nonobstructive HCM

This entry was posted in Cardiovascular Diseases and tagged Aficamten Efficacy HCM Nonobstructive Safety on

In patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), aficamten significantly improved exercise capacity and patient-reported health status compared with placebo at 36 weeks. In this phase 3 multinational, double-blind trial, 517 adults were randomly assigned to receive aficamten or placebo for up to 72 weeks. At week 36, the Kansas […]

DOACs Reduce Cardiovascular Events in Atrial Fibrillation at Intermediate Stroke Risk

This entry was posted in Cardiovascular Diseases and tagged Atrial Fibrillation DOAC Efficacy Intermediate Stroke Risk Safety on

In patients with atrial fibrillation at intermediate risk for stroke, direct oral anticoagulant (DOAC) therapy significantly reduced the 24-month risk of a composite of stroke, systemic embolism, major bleeding, or cardiovascular death compared with no anticoagulation. In the Korean multicenter, open-label, adjudicator-masked randomized trial, 1,803 patients with a CHA₂DS₂-VASc score […]

Single-Dose Psilocybin Effective in Major Depression

This entry was posted in Mental Disorders and tagged Efficacy Major Depression Psilocybin Treatment on

A randomized clinical trial found that a single 25 mg dose of psilocybin produced rapid antidepressant effects in patients with moderate to severe recurrent major depressive disorder (MDD), with benefits emerging by day 2 and persisting for more than 3 months on several secondary measures. Conducted at the Northern Stockholm […]

Intensive BP Control Is Effective and Safe Across Low and High DBP Levels

This entry was posted in Cardiovascular Diseases and tagged BP-Levels Diastolic BP Efficacy High Blood Pressure Safety on

Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]

Early Zalunfiban Injection Effective for Major Heart Attack:

This entry was posted in Cardiovascular Diseases and tagged Efficacy Myocardial Infarction Safety Zalunfiban on

In patients with ST-segment elevation myocardial infarction (STEMI), early subcutaneous administration of zalunfiban significantly improved coronary artery patency and reduced the risk of adverse 30-day clinical outcomes without increasing severe bleeding. In an international, double-blind, placebo-controlled trial of 2,467 patients randomly assigned to receive zalunfiban (0.11 mg/kg or 0.13 mg/kg) […]

Efficacy and Safety of Different Exercises for Knee Osteoarthritis

This entry was posted in Uncategorized and tagged Efficacy Exercises Knee Osteoarthritis Safety on

A systematic review and network meta-analysis evaluated the efficacy and safety of different exercise modalities for managing knee osteoarthritis, including aerobic, flexibility, mind-body, neuromotor, strengthening, and mixed exercises. A total of 217 randomized controlled trials involving 15,684 participants were analyzed, with outcomes assessed at short-term (4 weeks), mid-term (12 weeks), […]

Digitoxin Effective in Patients with Heart Failure and Reduced Ejection Fraction

This entry was posted in Cardiovascular Diseases and tagged Digitoxin Efficacy Heart Failure on

An international, double-blind, placebo-controlled trial suggested that digitoxin modestly lowered the combined risk of death from any cause or hospital admission for worsening heart failure (HF) than placebo in patients with advanced HF receiving modern therapy. The trial evaluated digitoxin in 1,240 patients with chronic HF and reduced ejection fraction […]

Efficacy of Non-Surgical and Non-Interventional Treatments in Low Back Pain

This entry was posted in Uncategorized and tagged Back Pain Efficacy Treatment on

A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty evidence that non-steroidal anti-inflammatory drugs (NSAIDs) are efficacious for acute low back pain, and that exercise, spinal manipulative therapy, taping, antidepressants, and transient receptor potential vanilloid 1 (TRPV1) agonists are efficacious for chronic low back […]