Primary Prevention

Evolocumab Reduces First Major Cardiovascular Events in High-Risk Patients Without Known Significant Atherosclerosis

This entry was posted in Cardiovascular Diseases and tagged CVD PCSK9i Primary Prevention on

In high-risk patients with diabetes but no known significant atherosclerosis, treatment with evolocumab significantly reduced the risk of a first major cardiovascular event compared with placebo when added to statin therapy. This prespecified subgroup analysis of the VESALIUS-CV randomized, double-blind, placebo-controlled trial included 3,655 participants from 774 sites across 33 […]

Statins Still Beneficial in Old and Very Old Adults

This entry was posted in Cardiovascular Diseases and tagged Old Adults Primary Prevention Statins on

A Chinese sequential target trial emulation comparing matched cohorts initiating versus not initiating statin therapy suggested benefits and safety of statin therapy in adults aged ≥75 years, even ≥85 years. The trial included persons 75 years or older who met indications for statin initiation from January 2008 to December 2015 […]