A meta-analysis of 15 randomized controlled trials involving 4,824 patients with high blood pressure found that sacubitril/valsartan significantly improved multiple ambulatory blood pressure measures compared with angiotensin receptor blockers (ARBs) or calcium channel blockers (CCBs), with a favorable safety profile. Compared with ARBs or CCBs, sacubitril/valsartan reduced 24-hour systolic and […]
Higher levels of chronic systemic inflammation were associated with smaller left ventricular volumes, compensatory increases in heart rate, and substantially higher cardiovascular risk in a large UK Biobank study. Among 488,079 participants with metabolomic, proteomic, cardiac MRI, and longitudinal data, higher inflammation measured by glycoprotein acetyls (GlycA) was associated with […]
In patients with severe asymptomatic carotid artery stenosis, carotid revascularization—either carotid artery stenting (CAS) or carotid endarterectomy (CEA)—added to intensive medical management (IMM) did not significantly improve cognitive function compared with IMM alone over up to 4 years. The CREST-2 randomized clinical trials included 2,366 US patients, of whom 2,165 […]
A 2026 Cochrane systematic review and meta-analysis of 107 randomized trials involving 26,886 adults with coronary heart disease (CHD) found that exercise-based cardiac rehabilitation (CR), compared with no structured exercise, reduces myocardial infarction (MI) and all-cause hospitalizations, likely provides a small reduction in mortality, and improves health-related quality of life […]
Higher nighttime light exposure was associated with adverse changes in cardiac structure and function and increased risks of cardiovascular disease (CVD) events and death. In this UK Biobank population-based study, 11,071 participants with 7-day wrist-worn light measurements and subsequent cardiac MRI were evaluated, with high nighttime light exposure (>3 lux) […]
A systematic review and meta-analysis found that the prevalence of unruptured intracranial aneurysms (UIAs) is increasing, particularly over the past two decades, and that the rise is only partly explained by improved detection of small aneurysms and population ageing. The analysis included 162 studies involving 316,131 participants and 11,822 people […]
Silent atherosclerosis was detectable as early as young adulthood and became progressively more prevalent and extensive with age, with a later and steeper increase among women. In this prospective cohort study conducted in Denmark and Spain, 16,808 adults aged 18 to 70 years without known atherosclerotic cardiovascular disease underwent three-dimensional […]
In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease, complete coronary revascularization guided by functional coronary angiography significantly reduced both major cardiovascular events and key safety events compared with conventional angiography-guided treatment. In this international randomized trial, 1,823 patients whose culprit lesion had been successfully treated […]
The Fifth Universal Definition of Myocardial Infarction (MI) updates the classification of MI by defining three major clinical settings—primary MI, secondary MI, and procedure-related MI—to better reflect underlying pathophysiology, support clinical evaluation, and incorporate objective diagnostic criteria. Primary MI occurs spontaneously because of an acute coronary pathology; although most cases […]
In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse compared with anticoagulation alone, without a significant increase in clinically relevant or major bleeding. In this Czech multicenter, open-label, randomized trial, 558 […]