Approximately 21% of patients with phenotypically mild hypertrophic cardiomyopathy (HCM) experienced major adverse cardiovascular events (MACE) during a mean follow-up of seven years, highlighting that even apparently mild disease requires careful long-term monitoring. In this prospective analysis of 2,500 patients from the Sarcomeric Human Cardiomyopathy Registry, 21% developed MACE, including […]
An international analysis of nearly 1 million adults found that the long-standing differences in blood pressure and non-HDL cholesterol between older adults with obesity and those of normal weight have narrowed substantially over the past three decades, largely alongside increased use of antihypertensive and cholesterol-lowering medications. Researchers analyzed data from […]
Elevated lipoprotein(a) [Lp(a)] was associated with a substantially higher risk of developing coronary artery disease (CAD) when accompanied by higher levels of the inflammatory biomarker interleukin-6 (IL-6), highlighting the important role of inflammation in modifying cardiovascular risk. In this UK Biobank study of 43,512 adults without preexisting CAD or aortic […]
The Second Universal Definition of Heart Failure (HF) introduces a standardized global framework that updates how HF is defined, classified, prevented, and managed, with the goal of improving patient care and cardiovascular health worldwide. Recognizing the growing burden of HF and the limitations of previous definitions, international cardiac societies and […]
Children and adolescents who regularly consume sugar-sweetened beverages (SSBs) and fruit juice may face a significantly higher risk of developing high blood pressure (BP) in adulthood, whereas whole fruit consumption does not appear to increase risk. In the Growing Up Today Study (GUTS), which followed 25,749 participants from a mean […]
Women who consistently performed resistance training had a substantially lower risk of major cardiovascular disease (CVD), particularly heart attacks, according to a prospective study involving more than 117,000 U.S. women followed for an average of 14.5 years. Compared with women who did no resistance training, those engaging in at least […]
The impact of late-life high blood pressure (BP) on dementia risk appears to depend on an older adult’s level of frailty, with high BP increasing dementia risk in robust individuals but not in those who are prefrail or frail. In this US prospective analysis of 5,093 dementia-free participants aged 67–89 […]
A Dutch randomized clinical trial found that two years of vitamin K2 (menaquinone-7, MK-7) supplementation significantly slowed the progression of coronary artery calcification (CAC) in patients with symptomatic coronary artery disease (CAD) compared with placebo. In the VitaK-CAC study, 180 patients with existing coronary calcification were randomized to receive either […]
Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]
An analysis from the FOURIER trial found that among patients with established atherosclerotic cardiovascular disease, lower lipoprotein(a) [Lp(a)] concentrations were associated with a higher prevalence of diabetes at baseline and a greater risk of developing diabetes during follow-up, while showing no increased risk of most other major adverse safety outcomes. […]