Women who consistently performed resistance training had a substantially lower risk of major cardiovascular disease (CVD), particularly heart attacks, according to a prospective study involving more than 117,000 U.S. women followed for an average of 14.5 years. Compared with women who did no resistance training, those engaging in at least […]
The impact of late-life high blood pressure (BP) on dementia risk appears to depend on an older adult’s level of frailty, with high BP increasing dementia risk in robust individuals but not in those who are prefrail or frail. In this US prospective analysis of 5,093 dementia-free participants aged 67–89 […]
A Dutch randomized clinical trial found that two years of vitamin K2 (menaquinone-7, MK-7) supplementation significantly slowed the progression of coronary artery calcification (CAC) in patients with symptomatic coronary artery disease (CAD) compared with placebo. In the VitaK-CAC study, 180 patients with existing coronary calcification were randomized to receive either […]
Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]
An analysis from the FOURIER trial found that among patients with established atherosclerotic cardiovascular disease, lower lipoprotein(a) [Lp(a)] concentrations were associated with a higher prevalence of diabetes at baseline and a greater risk of developing diabetes during follow-up, while showing no increased risk of most other major adverse safety outcomes. […]
Long-term follow-up of two randomized lifestyle intervention trials found that reducing visceral fat—not simply losing weight—was strongly associated with sustained cardiometabolic health benefits, and every 10% reduction in visceral fat lowered the future risk of type 2 diabetes by 28%. Researchers followed 366 participants from the 18-month CENTRAL and DIRECT-PLUS […]
A sham-controlled randomized trial demonstrated that pulsed field ablation (PFA) markedly reduced atrial fibrillation (AF) recurrence and burden while significantly improving quality of life and psychological distress compared with a sham procedure in highly symptomatic AF patients. In this single-blind study, 60 patients with severe AF-related quality-of-life impairment were randomized […]
A French prospective cohort study found that higher exposure to preservative food additives commonly used in industrial foods was associated with increased risks of high blood pressure and cardiovascular disease (CVD). Researchers analyzed data from 112,395 adults in the NutriNet-Santé cohort with a median follow-up of 7.9 years, using repeated […]
Coronary microvascular dysfunction (CMD) was common in patients undergoing invasive coronary angiography and was associated with nearly double the risk of major cardiovascular events. In this prospective multicenter study from South Korea involving 1,003 patients with suspected ischemic heart disease, CMD was identified in 21.5% of patients with obstructive epicardial […]
Early initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors after Takotsubo syndrome was associated with significantly lower all-cause mortality in a large real-world U.S. study, although reductions in cardiovascular complications were not observed. Using the TriNetX U.S. Collaborative Network, researchers identified adults diagnosed with Takotsubo syndrome between 2015 and 2025 and compared […]