A multicohort genetic association study found that the ancestry-enriched CD36 Y325* variant accounted for a greater population-level burden of dilated cardiomyopathy (DCM) among individuals of predominantly African ancestry than truncating variants in TTN, the most common established monogenic cause of DCM. Across four US cohorts involving 82,623 individuals of predominantly […]
An American College of Cardiology scientific statement emphasizes that exercise should be prescribed as a core component of cardiovascular disease (CVD) prevention and management, with the greatest absolute benefits occurring when physically inactive individuals begin exercising. The statement provides practical guidance for tailoring aerobic, resistance, balance, and flexibility training to […]
A systematic review and meta-analysis of 27 studies involving 88,830 participants found that intensive blood pressure (BP) lowering reduced the risk of major cardiovascular events by 15% for every 10-mm Hg reduction in systolic BP, regardless of chronic kidney disease (CKD) status. The estimated absolute reduction was 4.3 cardiovascular events […]
In an international multicenter cohort of 4,302 individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and high blood pressure, renin–angiotensin system inhibitor (RASi) and calcium channel blocker (CCB) use was associated with more favorable liver outcomes and a lower risk of long-term liver-related events (LREs). Over a median follow-up of […]
Preventive PCI was associated with a substantially lower risk of major cardiac events in patients with near-infrared spectroscopy–defined lipid-rich plaques (LRPs), but not in those without LRPs, suggesting that plaque composition may be more informative than plaque size alone in selecting lesions for preventive treatment. In this post hoc analysis […]
A healthy, balanced dietary pattern—not an emphasis on individual nutrients or foods—is central to preventing and managing cardiovascular and cardiometabolic disease, according to a new American College of Cardiology Scientific Statement. The statement reviews evidence on macronutrients, micronutrients, dietary patterns, ultra-processed foods, and emerging nutrition-based interventions, emphasizing that heart-healthy eating […]
Isometric exercise training (IET) performed just 1–2 times per week can partially preserve the blood pressure (BP)-lowering benefits achieved after an initial 4-week program, although exercising 3 times per week provides the strongest and most sustained effects. In this UK randomized study of 100 adults with normal to high-normal BP, […]
Heart failure (HF) affects nearly 1 in 4 Americans over their lifetime, and its growing prevalence, rising mortality, widening disparities, and persistent undertreatment have made it an increasingly urgent public health crisis. About one-third of U.S. adults without symptomatic HF are already at risk (Stage A), while another 24–34% have […]
A meta-analysis of 15 randomized controlled trials involving 4,824 patients with high blood pressure found that sacubitril/valsartan significantly improved multiple ambulatory blood pressure measures compared with angiotensin receptor blockers (ARBs) or calcium channel blockers (CCBs), with a favorable safety profile. Compared with ARBs or CCBs, sacubitril/valsartan reduced 24-hour systolic and […]
Higher levels of chronic systemic inflammation were associated with smaller left ventricular volumes, compensatory increases in heart rate, and substantially higher cardiovascular risk in a large UK Biobank study. Among 488,079 participants with metabolomic, proteomic, cardiac MRI, and longitudinal data, higher inflammation measured by glycoprotein acetyls (GlycA) was associated with […]