Cardiovascular Diseases

Long-Term Outcomes of Invasive vs Conservative Management in Stable Coronary Disease: Consistent Evidence From Extended Follow-Up Trials

This entry was posted in Cardiovascular Diseases and tagged Conservative Invasive Mortality Myocardial Infarction Stable Coronary Disease Treatment on

Extended follow-up of three major trials consistently shows that an initial invasive strategy does not improve long-term survival or reduce myocardial infarction (MI) compared with initial conservative management in patients with stable coronary disease. In the COURAGE trial’s extended observational analysis of 959 US veterans (median follow-up 15 years, maximum […]

Intensive BP Control Reduces Cardiovascular Events After Ischemic Stroke

This entry was posted in Cardiovascular Diseases and tagged Clinical Trial CVD Intensive Blood Pressure Control Prevention Safety Stroke on

Targeting a systolic blood pressure (BP) of less than 120 mm Hg lowered the incidence of major cardiovascular events compared with a target of less than 140 mm Hg among participants with elevated BP and a previous ischemic stroke or transient ischemic attack, according to a multicenter, open-label, randomized trial […]

No Significant Reduction in Major Cardiovascular Events with Intensive BP Lowering in T2D

This entry was posted in Cardiovascular Diseases Uncategorized and tagged Clinical Trial CVD Intensive BP Lowering T2D on

In patients with type 2 diabetes (T2D) and high cardiovascular risk, targeting a systolic blood pressure (BP) of less than 120 mm Hg did not significantly reduce major cardiovascular events compared with a target of less than 140 mm Hg, according to a multicenter, open-label, randomized trial conducted in Brazil. […]

Stopping Statins Noninferior to Continuing Them in Older Adults without Known CVD

This entry was posted in Cardiovascular Diseases and tagged CVD Discontinuation Old Adults Primary Prevention Statins on

Among older adults with at least two chronic conditions but no known cardiovascular disease, discontinuing statin therapy was noninferior to continuing it with respect to major cardiovascular events or death from any cause at 2 years. In this international, open-label, randomized, controlled trial, 1,880 adults aged 70 years or older […]

Ziltivekimab and Pelacarsen Show No Clinical Benefit Despite Effective Biomarker Lowering

This entry was posted in Cardiovascular Diseases and tagged CHD Efficacy Pelacarsen Safety Ziltivekimab on

Two randomized, placebo-controlled trials of targeted therapies—ziltivekimab, a monoclonal antibody neutralizing interleukin-6, and pelacarsen, an antisense oligonucleotide lowering lipoprotein(a)—both failed to reduce major adverse cardiovascular events despite effectively lowering their respective biomarkers. In the ziltivekimab trial, 6,376 adults with established atherosclerotic cardiovascular disease, chronic kidney disease, and cardiovascular inflammation (high-sensitivity […]

Cold Drives Heart Failure Hospitalizations in Older US Adults

This entry was posted in Cardiovascular Diseases and tagged Cold Heart Failure Hospitalization Older Adults on

Among US Medicare beneficiaries, colder ambient temperatures were associated with increased heart failure hospitalizations while warmer temperatures were not, and the U-shaped temperature–cardiovascular risk association seen for cardiovascular mortality did not apply to heart failure hospitalizations, according to a time-stratified case-crossover study of 1,517,756 hospitalizations from 996,312 patients (mean age, […]

No Significant Difference Between Initial CTO-PCI and No CTO-PCI Strategies in 10-Year Follow-Up

This entry was posted in Cardiovascular Diseases and tagged CAD Chronic Total Occlusion Follow-Up PCI on

In the 10-year extended follow-up of the DECISION-CTO trial, an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) was not associated with a significant difference in the primary composite endpoint of death, myocardial infarction, stroke, or any revascularization compared with a no CTO-PCI strategy (33.9% vs […]

CCTA-Guided PCI Noninferior to IVUS-Guided PCI

This entry was posted in Cardiovascular Diseases and tagged CCTA CHD IVUS PCI on

In a randomized, open-label, noninferiority trial, a coronary computed tomographic angiography (CCTA)–guided percutaneous coronary intervention (PCI) strategy was noninferior to intravascular ultrasound (IVUS)–guided PCI with respect to target-vessel failure at 12 months; among 1,105 randomized patients, target-vessel failure occurred in 4.1% of the CCTA-guided group versus 4.6% of the IVUS-guided […]

Left Bundle-Branch Area Pacing vs Right Ventricular Pacing in Atrioventricular Block

This entry was posted in Cardiovascular Diseases and tagged Atrioventricular Block Left Bundle-Branch Pacing Right Ventricular on

A randomized trial found that left bundle-branch area pacing (LBBAP) significantly reduced the risk of major clinical events, particularly heart failure (HF) events, compared with right ventricular pacing (RVP) in patients with atrioventricular block, preserved left ventricular ejection fraction (LVEF ≥50%), and an anticipated high ventricular pacing burden. The trial […]

Familial Hypercholesterolaemia Linked to Accelerated Thymic Ageing

This entry was posted in Cardiovascular Diseases Uncategorized and tagged Familial Hypercholesterolaemia Statin Treatment Thymic Ageing on

Familial hypercholesterolaemia (FH) is associated with reduced thymic output and accelerated thymic ageing, while statin treatment may help preserve immune cell production. In a Chinese study of 562 patients with heterozygous FH and 295 age-matched healthy controls, researchers found that untreated FH patients had a significantly lower proportion of recent […]