Cardiovascular Diseases

Evolocumab Reduces First Major Cardiovascular Events in High-Risk Patients Without Known Significant Atherosclerosis

This entry was posted in Cardiovascular Diseases and tagged CVD PCSK9i Primary Prevention on

In high-risk patients with diabetes but no known significant atherosclerosis, treatment with evolocumab significantly reduced the risk of a first major cardiovascular event compared with placebo when added to statin therapy. This prespecified subgroup analysis of the VESALIUS-CV randomized, double-blind, placebo-controlled trial included 3,655 participants from 774 sites across 33 […]

Elevated Aldosterone-Renin Ratio Tied to Atrial Fibrillation and Stroke in Older Adults

This entry was posted in Cardiovascular Diseases and tagged Aldosteronism Atrial Fibrillation Stroke on

A prospective US cohort study leveraging data from 3,477 participants (mean age 74.8 years; 61.5% female) in the Atherosclerosis Risk in Communities (ARIC) study has found that higher aldosterone-renin ratio (ARR) is independently associated with increased cardiovascular risk over nearly a decade of follow-up. Researchers measured serum aldosterone and renin […]

Statin Adverse Effects Analysis: Separating Signal from Noise

This entry was posted in Cardiovascular Diseases and tagged Adverse Effects Meta analysis Statins on

To address uncertainties in statin safety profiles, which are often based on observational data susceptible to bias, researchers conducted a definitive meta-analysis of individual participant data from major double-blind, randomized controlled trials. The study first identified all undesirable effects listed in the official Summaries of Product Characteristics (SmPCs) for five […]

Key US Updates in Acute Ischemic Stroke Management

This entry was posted in Cardiovascular Diseases and tagged Acute Ischemic Stroke Update on

Recent US stroke guidelines incorporate significant advances across the care continuum. Mobile Stroke Units (MSUs) are now recommended for their ability to accelerate thrombolysis. For suspected large vessel occlusion, bypassing to an endovascular thrombectomy (EVT)-capable center is endorsed when efficient. Intravenous thrombolysis (IVT) guidelines now include tenecteplase as non-inferior to […]

Salty Drinking Water Linked to Higher Blood Pressure, Especially in Coastal Communities

This entry was posted in Cardiovascular Diseases and tagged High Blood Pressure Salty Drinking Water on

A systematic review and meta-analysis of 27 observational studies, encompassing over 74,000 participants from 7 countries, indicates that consuming water with higher salinity is associated with increased blood pressure and hypertension risk. The analysis found that higher drinking water salinity was linked to average increases of 3.22 mm Hg in […]

Specific Mental Disorders Significantly Increase the Risk of Acute Coronary Syndrome

This entry was posted in Cardiovascular Diseases Mental Disorders on

According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 […]

Night Shift Work Linked to Higher Cardiovascular–Kidney–Metabolic Risk, Especially With Short Sleep

This entry was posted in Cardiovascular Diseases Uncategorized and tagged CKM NightShift Risks Sleep on

Long-term and intensive night shift work was associated with a significantly higher risk of cardiovascular–kidney–metabolic (CKM) disease in a large UK Biobank cohort, with the strongest effects seen among individuals who slept six hours or less per night. Among 96,365 participants followed through 2022, those with more than 20 years […]

Stress-Related Brain Activity Partly Explains the Link between Depression, Anxiety, and Cardiac Events

This entry was posted in Cardiovascular Diseases Mental Disorders and tagged Anxiety Brain Activity Cardiac Events Depression on

Depression and anxiety were each associated with a higher risk of major adverse cardiac events, with the greatest risk observed when both conditions co-occurred, and these associations were partly mediated by heightened stress-related neural activity and downstream autonomic and inflammatory dysregulation. In more than 85,000 participants from the Mass General […]

Prediabetes Remission Confers Long-Term Protection against CVD

This entry was posted in Cardiovascular Diseases Uncategorized and tagged Blood Glucose CVD Prevention on

Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]

2025 Key Updates in the Care of Adults with Congenital Heart Disease

This entry was posted in Cardiovascular Diseases and tagged ACHD Guideline Updates on

Recent recommendations of the American College of Cardiology/American Heart Association Joint Committee emphasize that adults with congenital heart disease achieve better outcomes when managed at specialized adult congenital heart disease (ACHD) centers with multidisciplinary teams and close involvement of ACHD cardiologists, particularly for patients with moderate or complex anatomy or […]