US Adults with prediabetes who participated in an intensive lifestyle intervention had a significantly lower risk of developing multiple chronic diseases over 25 years, while metformin did not provide a similar benefit. This long-term follow-up of the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS) included 1,173 […]
Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]
Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]
Traditional atherosclerotic cardiovascular disease (ASCVD) risk- and symptom-based screening misses nearly half of patients under age 66 who go on to experience their first myocardial infarction (MI), revealing major shortcomings in current preventive strategies. In this US retrospective study of 465 adults presenting with a first type 1 MI, simulation […]
Low-dose colchicine reduces myocardial infarction and stroke in people with cardiovascular disease (CVD) without increasing serious adverse events, although it raises the risk of mild gastrointestinal symptoms and shows no clear effect on mortality or revascularization. In an updated Cochrane review of 12 randomized controlled trials including 22,983 participants followed […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]
A Spanish secondary prevention study suggested that Mediterranean diet might reduce neutrophil levels and slow the progression of atherosclerosis and was superior to a low-fat diet in preventing major events of coronary heart disease (CHD). A total of 1002 CHD patients were randomly assigned to follow either a low-fat diet […]
A meta-analysis and a meta-regression of randomized clinical trials suggested that more intensive differential blood pressure (BP)–lowering may be beneficial for prevention of recurrent stroke and major cardiovascular events. The analysis included 10 randomized clinical trials comprising 40 710 patients (women 34%; mean age 65 years) with stroke or transient ischemic […]
The US Preventive Services Task Force recommends against initiating low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) in adults 60 years or older. The decision to initiate low-dose aspirin use for the primary prevention of CVD in adults aged 40 to 59 years who have a 10% […]
A Canadian study demonstrated that preactivating lower body muscle (PREACT) and leg crossing with muscle tensing (TENSE) after standing attenuates symptoms and blood pressure (BP) drop of initial orthostatic hypotension (IOH) upon standing. The study included 24 female IOH participants (mean ± SD: 32 ± 8 years) completed 3 sit-to-stand […]