Two-dose recombinant zoster vaccination (RZV) was associated with a significantly lower risk of new-onset dementia, including Alzheimer’s disease (AD) and vascular dementia (VD), among U.S. adults aged 65 years or older. In this Medicare-based study, individuals who received RZV were matched to unvaccinated counterparts by age, sex, and race/ethnicity, all […]
Higher consumption of ultra-processed foods (UPFs) is associated with poorer attention and increased modifiable dementia risk, independent of overall diet quality. In this cross-sectional study of 2,192 dementia-free Australian adults aged 40–70 years, dietary intake was assessed using a validated food frequency questionnaire and categorized by the Nova classification system, […]
Anemia was associated with higher levels of Alzheimer disease (AD) blood biomarkers and a markedly increased long-term risk of dementia, with the highest risk observed when low hemoglobin coexisted with elevated neurodegenerative markers. In a population-based cohort from the Swedish National Study on Aging and Care in Kungsholmen, 2,282 dementia-free […]
Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
A new study investigating the link between cerebral microbleeds (CMBs) and dementia has found that the location and pattern of these brain lesions are critical to assessing risk. Analyzing data from over 1,500 participants in the ARIC-Neurocognitive Study, researchers classified individuals based on their CMB patterns—lobar, subcortical, or mixed—and tracked […]
A large natural experiment study in Ontario, Canada, found that receiving the live attenuated herpes zoster vaccine significantly reduced the risk of a new dementia diagnosis by approximately 18% in adults aged 70 and older, providing the strongest evidence to date for a potential causal protective effect. The research leveraged […]
Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]
Higher physical activity may slow cognitive and functional decline in older adults at risk for Alzheimer’s disease (AD) by reducing tau accumulation rather than amyloid burden. In a study of cognitively unimpaired older adults with pedometer-measured step counts, greater physical activity was linked to slower decline among those with elevated […]
A combined observational and genetic study indicates that all levels of alcohol consumption may raise dementia risk, and reducing alcohol use disorder (AUD) could help lower dementia incidence at the population level. The study investigated the relationship between alcohol consumption and dementia using prospective cohort, case–control, and Mendelian randomization analyses […]
A US cohort study revealed genotype-dependent metabolic signatures of cognitive health and support precision nutrition approaches, such as Mediterranean diet for Alzheimer’s disease and related dementias (AD/ADRD) prevention. The study analyzed genetic, plasma metabolomic, and dietary data from 4,215 women and 1,490 men in prospective cohorts. The associations between 57 […]