Dementia risk factors vary substantially across countries, but they frequently cluster together in similar patterns worldwide, supporting both context-specific prevention strategies and multidomain interventions. In this comparative cross-sectional study of 214,251 adults aged 50 years and older from 14 countries and regions spanning high-income countries and low- and middle-income countries, […]
Older adults with biological signs of Alzheimer’s disease or neurodegeneration who adhered more closely to an anti-inflammatory dietary pattern had a significantly lower risk of developing dementia. In this Swedish population-based cohort study of 1,865 adults aged 60 years and older without dementia at baseline, researchers examined three healthy dietary […]
Higher daytime light exposure was associated with a significantly lower risk of developing dementia, while nighttime light exposure showed no significant relationship. In this study of 87,577 dementia-free UK adults (average age 62 years) followed for a median of 8.1 years, 741 participants developed dementia. Researchers measured light exposure using […]
The impact of late-life high blood pressure (BP) on dementia risk appears to depend on an older adult’s level of frailty, with high BP increasing dementia risk in robust individuals but not in those who are prefrail or frail. In this US prospective analysis of 5,093 dementia-free participants aged 67–89 […]
A U.S. study found that receiving the recombinant herpes zoster vaccine (RZV, shingles vaccine) was associated with a significantly lower risk of developing dementia among older adults admitted to skilled-nursing facilities. Researchers analyzed data from 509,926 Medicare beneficiaries aged 66 years or older who had no prior dementia diagnosis and […]
A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]
Recently identified brain rhythm during sleep may play a crucial role in clearing neurotoxic waste and protecting against dementia. Unlike wakefulness, when major neuromodulators such as norepinephrine, acetylcholine, serotonin, and dopamine act relatively independently, sleep synchronizes their activity into coordinated oscillations occurring approximately every 50 seconds. These rhythmic fluctuations are […]
A longitudinal study using data from the Alzheimer’s Disease Neuroimaging Initiative found that omega-3 fatty acid supplementation was associated with accelerated cognitive decline in older adults, challenging the common belief that omega-3 universally protects brain health. Participants taking omega-3 supplements showed faster worsening in MMSE, ADAS-Cog13, and CDR-SB scores over […]
Accelerometer-derived sleep-wake cycle patterns were associated with a higher risk of future dementia and modestly improved dementia prediction beyond traditional risk factors, with predictive value comparable to APOE genotype when added to an age-only model. In this large prospective cohort study involving more than 53,000 older adults from the UK […]
Two-dose recombinant zoster vaccination (RZV) was associated with a significantly lower risk of new-onset dementia, including Alzheimer’s disease (AD) and vascular dementia (VD), among U.S. adults aged 65 years or older. In this Medicare-based study, individuals who received RZV were matched to unvaccinated counterparts by age, sex, and race/ethnicity, all […]