Dementia risk factors vary substantially across countries, but they frequently cluster together in similar patterns worldwide, supporting both context-specific prevention strategies and multidomain interventions. In this comparative cross-sectional study of 214,251 adults aged 50 years and older from 14 countries and regions spanning high-income countries and low- and middle-income countries, […]
Children and adults with autism exhibit altered large-scale brain connectivity patterns compared with typically developing individuals, and these differences are most pronounced in a subtype characterized by lower language, intellectual, and adaptive functioning (LIAF). Using data-driven clustering of standardized phenotypic measures from 419 individuals in the US National Institute of […]
Older adults with biological signs of Alzheimer’s disease or neurodegeneration who adhered more closely to an anti-inflammatory dietary pattern had a significantly lower risk of developing dementia. In this Swedish population-based cohort study of 1,865 adults aged 60 years and older without dementia at baseline, researchers examined three healthy dietary […]
Higher daytime light exposure was associated with a significantly lower risk of developing dementia, while nighttime light exposure showed no significant relationship. In this study of 87,577 dementia-free UK adults (average age 62 years) followed for a median of 8.1 years, 741 participants developed dementia. Researchers measured light exposure using […]
The impact of late-life high blood pressure (BP) on dementia risk appears to depend on an older adult’s level of frailty, with high BP increasing dementia risk in robust individuals but not in those who are prefrail or frail. In this US prospective analysis of 5,093 dementia-free participants aged 67–89 […]
A U.S. study found that receiving the recombinant herpes zoster vaccine (RZV, shingles vaccine) was associated with a significantly lower risk of developing dementia among older adults admitted to skilled-nursing facilities. Researchers analyzed data from 509,926 Medicare beneficiaries aged 66 years or older who had no prior dementia diagnosis and […]
A Danish population-based cohort study found that individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) in more recent years carried lower average genetic risk scores for these conditions and related psychiatric traits than those diagnosed earlier, suggesting that the rising prevalence of ADHD and ASD is more […]
A new study identifies brain hyperglycosylation—an excessive buildup of sugar-containing glycans on proteins—as a pathological driver of Alzheimer’s disease (AD), revealing a promising new target for treatment. By integrating spatial metabolomics, lipidomics, glycomics, and advanced isotopic tracing techniques in transgenic AD mouse models and post-mortem human brain samples, researchers found […]
Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]
A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]