Anemia was associated with higher levels of Alzheimer disease (AD) blood biomarkers and a markedly increased long-term risk of dementia, with the highest risk observed when low hemoglobin coexisted with elevated neurodegenerative markers. In a population-based cohort from the Swedish National Study on Aging and Care in Kungsholmen, 2,282 dementia-free […]
Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
A new study investigating the link between cerebral microbleeds (CMBs) and dementia has found that the location and pattern of these brain lesions are critical to assessing risk. Analyzing data from over 1,500 participants in the ARIC-Neurocognitive Study, researchers classified individuals based on their CMB patterns—lobar, subcortical, or mixed—and tracked […]
A large natural experiment study in Ontario, Canada, found that receiving the live attenuated herpes zoster vaccine significantly reduced the risk of a new dementia diagnosis by approximately 18% in adults aged 70 and older, providing the strongest evidence to date for a potential causal protective effect. The research leveraged […]
According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 […]
Depression and anxiety were each associated with a higher risk of major adverse cardiac events, with the greatest risk observed when both conditions co-occurred, and these associations were partly mediated by heightened stress-related neural activity and downstream autonomic and inflammatory dysregulation. In more than 85,000 participants from the Mass General […]
In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]
Slow tapering with psychological support is just as effective as continuing antidepressants—and clearly safer than abrupt or rapid discontinuation—in preventing relapse among people whose depression is in remission. In this systematic review and network meta-analysis of 76 trials including 17,379 adults with remitted depression or anxiety, several strategies outperformed abrupt […]
Better mental wellbeing substantially reduces the risk of developing irritable bowel syndrome (IBS), with effects that are independent of genetic predisposition and partly mediated through lower depression and anxiety. In this prospective UK Biobank cohort of 75,842 IBS-free participants followed for 12.4 years, 1,400 incident IBS cases occurred, and higher […]
Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]