In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]
Slow tapering with psychological support is just as effective as continuing antidepressants—and clearly safer than abrupt or rapid discontinuation—in preventing relapse among people whose depression is in remission. In this systematic review and network meta-analysis of 76 trials including 17,379 adults with remitted depression or anxiety, several strategies outperformed abrupt […]
Better mental wellbeing substantially reduces the risk of developing irritable bowel syndrome (IBS), with effects that are independent of genetic predisposition and partly mediated through lower depression and anxiety. In this prospective UK Biobank cohort of 75,842 IBS-free participants followed for 12.4 years, 1,400 incident IBS cases occurred, and higher […]
Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]
Higher physical activity may slow cognitive and functional decline in older adults at risk for Alzheimer’s disease (AD) by reducing tau accumulation rather than amyloid burden. In a study of cognitively unimpaired older adults with pedometer-measured step counts, greater physical activity was linked to slower decline among those with elevated […]
A study shows that autism diagnosed earlier versus later in life may reflect different developmental pathways and genetic profiles. In longitudinal data from four birth cohorts, there were two distinct socioemotional and behavioral trajectories tied to age at autism diagnosis. Genetic factors explained about 11% of the variation in when […]
A combined observational and genetic study indicates that all levels of alcohol consumption may raise dementia risk, and reducing alcohol use disorder (AUD) could help lower dementia incidence at the population level. The study investigated the relationship between alcohol consumption and dementia using prospective cohort, case–control, and Mendelian randomization analyses […]
A US longitudinal population-based cohort study suggests that chronic insomnia, especially with reduced sleep, is a risk factor for cognitive decline and adverse brain health in older adults. Researchers followed cognitively unimpaired participants who underwent annual neuropsychological testing and brain imaging (amyloid-PET and MRI for white matter hyperintensities [WMH]) over […]
A US cohort study revealed genotype-dependent metabolic signatures of cognitive health and support precision nutrition approaches, such as Mediterranean diet for Alzheimer’s disease and related dementias (AD/ADRD) prevention. The study analyzed genetic, plasma metabolomic, and dietary data from 4,215 women and 1,490 men in prospective cohorts. The associations between 57 […]
A systematic review and meta-analysis indicate that while antidepressant discontinuation is associated with a mild increase in physical symptoms, the average symptom burden does not reach the threshold for clinically significant discontinuation syndrome. Researchers examined symptoms using standardized measures such as the Discontinuation-Emergent Signs and Symptoms (DESS) scale and tracked […]