A Danish population-based cohort study found that individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) in more recent years carried lower average genetic risk scores for these conditions and related psychiatric traits than those diagnosed earlier, suggesting that the rising prevalence of ADHD and ASD is more […]
A new study identifies brain hyperglycosylation—an excessive buildup of sugar-containing glycans on proteins—as a pathological driver of Alzheimer’s disease (AD), revealing a promising new target for treatment. By integrating spatial metabolomics, lipidomics, glycomics, and advanced isotopic tracing techniques in transgenic AD mouse models and post-mortem human brain samples, researchers found […]
Preventing progression and promoting regression of cardiovascular-kidney-metabolic (CKM) syndrome requires early staging, comprehensive risk assessment, management of risk factors, and use of evidence-based therapies across the life course. CKM syndrome staging is recommended for youths and adults to guide treatment and reduce cardiovascular and kidney complications. Individuals with CKM stages […]
A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]
Recently identified brain rhythm during sleep may play a crucial role in clearing neurotoxic waste and protecting against dementia. Unlike wakefulness, when major neuromodulators such as norepinephrine, acetylcholine, serotonin, and dopamine act relatively independently, sleep synchronizes their activity into coordinated oscillations occurring approximately every 50 seconds. These rhythmic fluctuations are […]
A US community-based study found that middle-aged adults with blood biomarkers indicating Alzheimer’s disease neuropathology already showed worse cognition and faster cognitive decline years before dementia diagnosis. Researchers analyzed 1,350 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent plasma biomarker testing at year 35 […]
A randomized clinical trial found that a single 25 mg dose of psilocybin produced rapid antidepressant effects in patients with moderate to severe recurrent major depressive disorder (MDD), with benefits emerging by day 2 and persisting for more than 3 months on several secondary measures. Conducted at the Northern Stockholm […]
A US prospective real-world study of 357 adults with Irritable Bowel Syndrome (IBS) found that higher daily stress levels were strongly associated with worse IBS symptom severity, and stress and symptoms appeared to reinforce each other especially from the afternoon into the evening. Researchers followed adults meeting Rome IV criteria […]
A longitudinal study using data from the Alzheimer’s Disease Neuroimaging Initiative found that omega-3 fatty acid supplementation was associated with accelerated cognitive decline in older adults, challenging the common belief that omega-3 universally protects brain health. Participants taking omega-3 supplements showed faster worsening in MMSE, ADAS-Cog13, and CDR-SB scores over […]
Accelerometer-derived sleep-wake cycle patterns were associated with a higher risk of future dementia and modestly improved dementia prediction beyond traditional risk factors, with predictive value comparable to APOE genotype when added to an age-only model. In this large prospective cohort study involving more than 53,000 older adults from the UK […]