Restricting sugar intake during the first 1,000 days from conception was associated with a lower risk of dementia, delayed disease onset by about 2.5–2.9 years, and better brain health in later life. Using the end of UK sugar rationing in September 1953 as a natural experiment, researchers analyzed 64,737 UK […]
Incidental coronary artery calcium (CAC) identified on routine nongated chest CT scans predicts future coronary heart disease (CHD) and cardiovascular disease (CVD) events with prognostic performance comparable to dedicated gated cardiac CT, supporting its incorporation into routine clinical practice for cardiovascular risk assessment. This study included 2,472 participants from the […]
Higher blood levels of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) were independently associated with an increased risk of developing abdominal aortic aneurysms (AAAs) and experiencing serious AAA-related events in apparently healthy older adults. Researchers measured plasma TMAO levels in 4,442 community-dwelling adults aged 65 years or older from the […]
Accelerated biological aging was associated with a higher risk of early-onset solid cancers in young adults, particularly lung, gastrointestinal, and uterine cancers, suggesting that biological aging may help explain the rising incidence of cancer in recent generations. In a study of 154,169 young adults from the UK Biobank, systemic biological […]
Men who started testosterone therapy (TT) without evidence of hypogonadism had significantly higher long-term risks of major adverse cardiovascular events (MACE), all-cause mortality, ischaemic stroke, cardiac arrest, and heart failure than men with documented hypogonadism. In this global retrospective real-world study of 358,957 men aged 30–75 years initiating TT, 35.4% […]
A nationwide Danish study found that recent use of several progestogen-containing contraceptives—including cyproterone, desogestrel, drospirenone, gestodene, levonorgestrel, injectable medroxyprogesterone, and high-dose levonorgestrel intrauterine devices (IUDs)—was associated with an increased risk of meningioma, with injectable medroxyprogesterone showing the strongest association. Researchers analyzed nationwide health registry data from approximately 3 million women […]
Higher coffee consumption was associated with substantially lower risks of cirrhosis, liver cancer, and liver-related death, while also showing favorable liver imaging and proteomic profiles in a prospective study of nearly 355,000 participants from the UK Biobank. During a median follow-up of 13 years, individuals who drank at least five […]
Elevated lipoprotein(a) [Lp(a)] was associated with a substantially higher risk of developing coronary artery disease (CAD) when accompanied by higher levels of the inflammatory biomarker interleukin-6 (IL-6), highlighting the important role of inflammation in modifying cardiovascular risk. In this UK Biobank study of 43,512 adults without preexisting CAD or aortic […]
Older adults with biological signs of Alzheimer’s disease or neurodegeneration who adhered more closely to an anti-inflammatory dietary pattern had a significantly lower risk of developing dementia. In this Swedish population-based cohort study of 1,865 adults aged 60 years and older without dementia at baseline, researchers examined three healthy dietary […]
Higher daytime light exposure was associated with a significantly lower risk of developing dementia, while nighttime light exposure showed no significant relationship. In this study of 87,577 dementia-free UK adults (average age 62 years) followed for a median of 8.1 years, 741 participants developed dementia. Researchers measured light exposure using […]