Targeting a systolic blood pressure (BP) of less than 120 mm Hg lowered the incidence of major cardiovascular events compared with a target of less than 140 mm Hg among participants with elevated BP and a previous ischemic stroke or transient ischemic attack, according to a multicenter, open-label, randomized trial […]
In patients with type 2 diabetes (T2D) and high cardiovascular risk, targeting a systolic blood pressure (BP) of less than 120 mm Hg did not significantly reduce major cardiovascular events compared with a target of less than 140 mm Hg, according to a multicenter, open-label, randomized trial conducted in Brazil. […]
Among older adults with at least two chronic conditions but no known cardiovascular disease, discontinuing statin therapy was noninferior to continuing it with respect to major cardiovascular events or death from any cause at 2 years. In this international, open-label, randomized, controlled trial, 1,880 adults aged 70 years or older […]
A new multisociety scientific statement introduces the Female Life Stage framework to improve cardiovascular disease prevention and management in girls and women by integrating hormonal, psychosocial, and cardiovascular health across the lifespan. These interconnected domains often experience concurrent dysregulation, which is associated with increased cardiovascular risk, yet care remains fragmented […]
A meta-analysis of 85 randomized clinical trials involving 70,543 participants found that sodium-glucose cotransporter 2 (SGLT2) inhibitors were associated with small but statistically significant increases in hemoglobin and hematocrit levels compared with control treatments, although the clinical significance of these changes remains unclear. The trials had a median follow-up of […]
An American College of Cardiology scientific statement emphasizes that exercise should be prescribed as a core component of cardiovascular disease (CVD) prevention and management, with the greatest absolute benefits occurring when physically inactive individuals begin exercising. The statement provides practical guidance for tailoring aerobic, resistance, balance, and flexibility training to […]
A systematic review and meta-analysis of 27 studies involving 88,830 participants found that intensive blood pressure (BP) lowering reduced the risk of major cardiovascular events by 15% for every 10-mm Hg reduction in systolic BP, regardless of chronic kidney disease (CKD) status. The estimated absolute reduction was 4.3 cardiovascular events […]
Preventive PCI was associated with a substantially lower risk of major cardiac events in patients with near-infrared spectroscopy–defined lipid-rich plaques (LRPs), but not in those without LRPs, suggesting that plaque composition may be more informative than plaque size alone in selecting lesions for preventive treatment. In this post hoc analysis […]
A healthy, balanced dietary pattern—not an emphasis on individual nutrients or foods—is central to preventing and managing cardiovascular and cardiometabolic disease, according to a new American College of Cardiology Scientific Statement. The statement reviews evidence on macronutrients, micronutrients, dietary patterns, ultra-processed foods, and emerging nutrition-based interventions, emphasizing that heart-healthy eating […]
Higher levels of chronic systemic inflammation were associated with smaller left ventricular volumes, compensatory increases in heart rate, and substantially higher cardiovascular risk in a large UK Biobank study. Among 488,079 participants with metabolomic, proteomic, cardiac MRI, and longitudinal data, higher inflammation measured by glycoprotein acetyls (GlycA) was associated with […]