CVD


Incidental Coronary Calcium on Routine Chest CT Predicts Future Cardiovascular Risk as Well as Dedicated Heart Scans

Incidental coronary artery calcium (CAC) identified on routine nongated chest CT scans predicts future coronary heart disease (CHD) and cardiovascular disease (CVD) events with prognostic performance comparable to dedicated gated cardiac CT, supporting its incorporation into routine clinical practice for cardiovascular risk assessment. This study included 2,472 participants from the […]


Moderate Coffee Consumption May Benefit the Cardiovascular System, but High Doses Caffeine Can Be Harmful

Moderate consumption of naturally caffeinated beverages, particularly coffee, is generally associated with a lower risk of several cardiovascular diseases, whereas high doses of caffeine—such as those found in many energy drinks—may increase cardiovascular risk. Caffeine is one of the world’s most widely consumed psychoactive substances, and its cardiovascular effects vary […]


Testosterone Therapy Without Hypogonadism Linked to Higher Long-Term Cardiovascular Risk

Men who started testosterone therapy (TT) without evidence of hypogonadism had significantly higher long-term risks of major adverse cardiovascular events (MACE), all-cause mortality, ischaemic stroke, cardiac arrest, and heart failure than men with documented hypogonadism. In this global retrospective real-world study of 358,957 men aged 30–75 years initiating TT, 35.4% […]


Resistance Training Significantly Lowers CVD Risk in Women

Women who consistently performed resistance training had a substantially lower risk of major cardiovascular disease (CVD), particularly heart attacks, according to a prospective study involving more than 117,000 U.S. women followed for an average of 14.5 years. Compared with women who did no resistance training, those engaging in at least […]


Preservative Food Additives Linked to Higher CVD Risks

A French prospective cohort study found that higher exposure to preservative food additives commonly used in industrial foods was associated with increased risks of high blood pressure and cardiovascular disease (CVD). Researchers analyzed data from 112,395 adults in the NutriNet-Santé cohort with a median follow-up of 7.9 years, using repeated […]


Coronary Microvascular Dysfunction Signals Higher Cardiovascular Risk

Coronary microvascular dysfunction (CMD) was common in patients undergoing invasive coronary angiography and was associated with nearly double the risk of major cardiovascular events. In this prospective multicenter study from South Korea involving 1,003 patients with suspected ischemic heart disease, CMD was identified in 21.5% of patients with obstructive epicardial […]


BP-Lowering Reduces Cardiovascular Risk Across All CKD Stages, with Attenuated Benefit in Diabetes

Blood pressure (BP)-lowering treatment significantly reduces the risk of major cardiovascular events in individuals with chronic kidney disease (CKD) across all stages, with effects comparable to those without CKD, although benefits are diminished in patients with coexisting diabetes. This one-stage individual-participant meta-analysis included 52 randomized controlled trials, of which 46 […]


Undiagnosed Heart Disease Account for a Large Share of Sudden Cardiac Deaths

While myocardial infarction (MI) accounts for a substantial proportion of sudden cardiac deaths (SCDs), most arrhythmic SCDs occur in individuals without previously diagnosed risk factors, often due to occult cardiac disease such as silent MI or dilated cardiomyopathy. In the 12-year US countywide POST SCD autopsy study, 943 presumed sudden […]


Calcium Supplementation Linked to Higher Risk of CVD Recurrence

In patients with established cardiovascular disease (CVD), calcium supplementation was associated with an increased risk of recurrent CVD events and related hospitalizations, particularly with calcium-only use and among men. In this large retrospective population-based study from Hong Kong, 17,720 matched patients receiving calcium supplements were compared with an equal number […]


Evolocumab Reduces First Major Cardiovascular Events in High-Risk Patients Without Known Significant Atherosclerosis

In high-risk patients with diabetes but no known significant atherosclerosis, treatment with evolocumab significantly reduced the risk of a first major cardiovascular event compared with placebo when added to statin therapy. This prespecified subgroup analysis of the VESALIUS-CV randomized, double-blind, placebo-controlled trial included 3,655 participants from 774 sites across 33 […]