A meta-analysis of 15 randomized controlled trials involving 4,824 patients with high blood pressure found that sacubitril/valsartan significantly improved multiple ambulatory blood pressure measures compared with angiotensin receptor blockers (ARBs) or calcium channel blockers (CCBs), with a favorable safety profile. Compared with ARBs or CCBs, sacubitril/valsartan reduced 24-hour systolic and […]
Children and adolescents who regularly consume sugar-sweetened beverages (SSBs) and fruit juice may face a significantly higher risk of developing high blood pressure (BP) in adulthood, whereas whole fruit consumption does not appear to increase risk. In the Growing Up Today Study (GUTS), which followed 25,749 participants from a mean […]
The impact of late-life high blood pressure (BP) on dementia risk appears to depend on an older adult’s level of frailty, with high BP increasing dementia risk in robust individuals but not in those who are prefrail or frail. In this US prospective analysis of 5,093 dementia-free participants aged 67–89 […]
A French prospective cohort study found that higher exposure to preservative food additives commonly used in industrial foods was associated with increased risks of high blood pressure and cardiovascular disease (CVD). Researchers analyzed data from 112,395 adults in the NutriNet-Santé cohort with a median follow-up of 7.9 years, using repeated […]
In patients with prior intracerebral hemorrhage, adding a single pill combining three low-dose antihypertensive agents to standard care significantly reduced recurrent stroke and major cardiovascular events compared with placebo. In this multinational, double-blind, randomized controlled trial of 1,670 clinically stable patients with baseline systolic blood pressure (BP) of 130–160 mm […]
A systematic review and meta-analysis of 27 observational studies, encompassing over 74,000 participants from 7 countries, indicates that consuming water with higher salinity is associated with increased blood pressure and hypertension risk. The analysis found that higher drinking water salinity was linked to average increases of 3.22 mm Hg in […]
Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]
The updated US guidelines for high blood pressure (HBP) emphasize that HBP is the most common and modifiable risk factor for cardiovascular diseases—including coronary artery disease, heart failure, atrial fibrillation, stroke, dementia, chronic kidney disease, and all-cause mortality—with a treatment goal of <130/80 mm Hg for most adults, while allowing […]
A recent US clinical trial explored two strategies for reducing sedentary behavior and their effects on health in overweight or obese postmenopausal women. Over a 3-month period, 407 participants were randomly assigned to one of three groups: a control group focused on general healthy living, a group aiming to reduce […]
A Chinese prospective, randomized, parallel-group, superiority clinical trial revealed that bedtime dosing provides superior nocturnal blood pressure (BP) control and circadian rhythm improvement without compromising daytime or 24-hour BP control. The trial was conducted at 15 hospitals in China between June 2022 and April 2024 with a 12-week follow-up, compared […]