Safety

Catheter-Directed Thrombolysis Improves Outcomes in Intermediate-High–Risk Pulmonary Embolism

This entry was posted in Cardiovascular Diseases and tagged Catheter-Directed Thrombolysis Efficacy Pulmonary Embolism Safety on

In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse compared with anticoagulation alone, without a significant increase in clinically relevant or major bleeding. In this Czech multicenter, open-label, randomized trial, 558 […]

Aficamten Improves Exercise Capacity and Health Status in Nonobstructive HCM

This entry was posted in Cardiovascular Diseases and tagged Aficamten Efficacy HCM Nonobstructive Safety on

In patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), aficamten significantly improved exercise capacity and patient-reported health status compared with placebo at 36 weeks. In this phase 3 multinational, double-blind trial, 517 adults were randomly assigned to receive aficamten or placebo for up to 72 weeks. At week 36, the Kansas […]

DOACs Reduce Cardiovascular Events in Atrial Fibrillation at Intermediate Stroke Risk

This entry was posted in Cardiovascular Diseases and tagged Atrial Fibrillation DOAC Efficacy Intermediate Stroke Risk Safety on

In patients with atrial fibrillation at intermediate risk for stroke, direct oral anticoagulant (DOAC) therapy significantly reduced the 24-month risk of a composite of stroke, systemic embolism, major bleeding, or cardiovascular death compared with no anticoagulation. In the Korean multicenter, open-label, adjudicator-masked randomized trial, 1,803 patients with a CHA₂DS₂-VASc score […]

Stopping Statins for Primary Prevention After Age 75? Evidence from a Randomized Trial

This entry was posted in Cardiovascular Diseases and tagged Discontinuation Old Adults Primary Prevention Safety Statins on

In adults aged 75 years or older without a history of atherosclerotic cardiovascular disease (ASCVD) who were taking statins for primary prevention, discontinuing statin therapy was non-inferior to continuing treatment with respect to 3-year all-cause mortality. In the French multicentre, open-label, phase 3 randomised controlled trial, 1,180 participants were assigned […]

Intensive BP Control Is Effective and Safe Across Low and High DBP Levels

This entry was posted in Cardiovascular Diseases and tagged BP-Levels Diastolic BP Efficacy High Blood Pressure Safety on

Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]

Early Zalunfiban Injection Effective for Major Heart Attack:

This entry was posted in Cardiovascular Diseases and tagged Efficacy Myocardial Infarction Safety Zalunfiban on

In patients with ST-segment elevation myocardial infarction (STEMI), early subcutaneous administration of zalunfiban significantly improved coronary artery patency and reduced the risk of adverse 30-day clinical outcomes without increasing severe bleeding. In an international, double-blind, placebo-controlled trial of 2,467 patients randomly assigned to receive zalunfiban (0.11 mg/kg or 0.13 mg/kg) […]

Updated Evidence Supports Current Vaccines Safety and Effectiveness

This entry was posted in Health Uncategorized and tagged Effectiveness Immunization Influenza RSV Safety on

Ongoing peer-reviewed evidence supports the safety and effectiveness of vaccines against Covid-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. In a systematic review of 511 studies out of 17,263 identified references, Covid-19 mRNA vaccines targeting the XBB.1.5 subvariant showed pooled effectiveness against hospitalization of 46% from cohort […]

Efficacy and Safety of Different Exercises for Knee Osteoarthritis

This entry was posted in Uncategorized and tagged Efficacy Exercises Knee Osteoarthritis Safety on

A systematic review and network meta-analysis evaluated the efficacy and safety of different exercise modalities for managing knee osteoarthritis, including aerobic, flexibility, mind-body, neuromotor, strengthening, and mixed exercises. A total of 217 randomized controlled trials involving 15,684 participants were analyzed, with outcomes assessed at short-term (4 weeks), mid-term (12 weeks), […]

Efficacy and Safety of Bempedoic Acid

This entry was posted in Cardiovascular Diseases and tagged Bempedoic Acid Efficacy Safety on

In the prespecified analysis of a randomized, double-blind, placebo-controlled trial, bempedoic acid reduces LDL cholesterol, high-sensitivity C-reactive protein, and risk of cardiovascular events among those with baseline diabetes, prediabetes, or normoglycemia, with or without cardiovascular disease at baseline. Between Dec 22, 2016, and Nov 7, 2022, 13 970 patients who were […]