A systematic review and network meta-analysis of 262 randomized trials involving 99,791 participants found that anti-obesity medications vary substantially in both effectiveness and safety, with greater weight loss generally accompanied by higher rates of adverse events and treatment discontinuation. At one year, tirzepatide and cagrilintide-semaglutide (CagriSema) produced the greatest confirmed […]
A 13-year follow-up of a randomized controlled trial found that a single colonoscopy screening significantly reduced colorectal cancer incidence but did not significantly lower mortality. In this multicountry study involving 84,583 adults aged 55–64 years from Norway, Poland, and Sweden, participants were randomized to receive colonoscopy screening or no screening. […]
A pooled analysis of lifestyle intervention trials suggested that adopting a healthy lifestyle can confer metabolic benefits beyond weight loss (WL) alone. The study investigated how individual responses to long-term lifestyle interventions for WL affect cardiometabolic risk by pooling data from three long-term lifestyle WL-intervention trials with adherence rates of […]