Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
A new study investigating the link between cerebral microbleeds (CMBs) and dementia has found that the location and pattern of these brain lesions are critical to assessing risk. Analyzing data from over 1,500 participants in the ARIC-Neurocognitive Study, researchers classified individuals based on their CMB patterns—lobar, subcortical, or mixed—and tracked […]
Long-term and intensive night shift work was associated with a significantly higher risk of cardiovascular–kidney–metabolic (CKM) disease in a large UK Biobank cohort, with the strongest effects seen among individuals who slept six hours or less per night. Among 96,365 participants followed through 2022, those with more than 20 years […]
In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]
A systematic review of 17 randomized trials involving 66,337 adults found that reducing or modifying saturated fat intake offers little or no clinically meaningful benefit over five years for people at low cardiovascular risk, but may lead to important reductions in mortality and major cardiovascular events among those at high […]
A multilipid score (MLS), reflecting the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations, was associated with significantly lower risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). The MLS was based on lipidomics data from a randomized controlled dietary intervention trial, replacing specific […]
The post hoc analysis of a UK prospective cohort study suggested that immune-mediated diseases were associated with risk of cancer at the local and systemic levels. The analysis included 478 753 participants (mean age, 56.4 years; 54% female) between 2006 and 2010, with follow-up through 2019. During 4 600 460 person-years of follow-up, […]
A multigenerational, prospective cohort study in the US concluded that early onset (age <55 years) compared with late onset hypertension was associated with greater odds of cardiovascular death and with greater risk for hypertension in offspring. The study included 3614 first generation participants with mortality data and 1635 initially non-hypertensive […]