The American Cancer Society (ACS) reaffirmed that average-risk adults should begin colorectal cancer (CRC) screening at age 45 and continue through age 75 if life expectancy exceeds 10 years, while emphasizing that stool-based screening tests remain the preferred noncolonoscopy options over newer blood-based tests. CRC remains a leading cause of […]
A comprehensive systematic review and meta-analysis involving 69 randomized controlled trials and 153,902 adults found that calcium supplements, vitamin D supplements, or their combination offer little to no clinically meaningful benefit in preventing fractures or falls in adults not taking osteoporosis medications. Most participants were community-dwelling individuals (87%) and were […]
A US prospective real-world study of 357 adults with Irritable Bowel Syndrome (IBS) found that higher daily stress levels were strongly associated with worse IBS symptom severity, and stress and symptoms appeared to reinforce each other especially from the afternoon into the evening. Researchers followed adults meeting Rome IV criteria […]
An updated Cochrane systematic review of five randomized controlled trials involving 341,342 men found that PSA-based prostate cancer screening did not significantly reduce prostate cancer-specific mortality or overall mortality when all studies were combined, although one major European study (ERSPC) showed a 21% reduction in prostate cancer deaths among men […]
A 13-year follow-up of a randomized controlled trial found that a single colonoscopy screening significantly reduced colorectal cancer incidence but did not significantly lower mortality. In this multicountry study involving 84,583 adults aged 55–64 years from Norway, Poland, and Sweden, participants were randomized to receive colonoscopy screening or no screening. […]
Blood pressure (BP)-lowering treatment significantly reduces the risk of major cardiovascular events in individuals with chronic kidney disease (CKD) across all stages, with effects comparable to those without CKD, although benefits are diminished in patients with coexisting diabetes. This one-stage individual-participant meta-analysis included 52 randomized controlled trials, of which 46 […]
A new clinical practice guideline from the American Academy of Sleep Medicine indicates that cognitive behavioral therapy for insomnia (CBT-I) alone remains the most effective first-line treatment for chronic insomnia, while adding medication may offer modest benefits for select outcomes such as total sleep time. The guideline is supported by […]
In older adults, longer and more frequent daytime naps, particularly those occurring in the morning, were associated with a higher risk of all-cause mortality based on objective actigraphy measurements. In this prospective cohort study from the US Rush Memory and Aging Project, 1,338 community-dwelling adults (mean age 81.4 years, 76% […]
A recent study suggests that daily multivitamin-mineral supplements could slightly slow the biological aging process in older adults, though the effect size is modest and requires further investigation. As part of the COSMOS trial, researchers analyzed data from 958 participants over two years using advanced “epigenetic clocks”—DNA methylation measures that […]
A rigorous cohort study utilizing Taiwan’s National Health Insurance Database provides robust evidence that SGLT2 inhibitors offer superior multi-organ protection for the complex population of patients with both type 2 diabetes and liver cirrhosis. Among 24,259 adults (average age 64.7 years; 33.9% female) followed for a median of 2.3 years, […]