Early-life sugar restriction during pregnancy and infancy was associated with a 34% lower risk of early-onset cancer (diagnosed by age 50), although it was not associated with a significant reduction in cancer-specific mortality. Using a natural experiment created by the end of UK sugar rationing, researchers analyzed 63,819 UK Biobank […]
In US adults aged ≥65 years, overweight and class I–II obesity were associated with lower all-cause mortality risk, whereas high waist circumference and being underweight were associated with higher mortality risk, highlighting the importance of central adiposity and the limitations of BMI alone for mortality risk stratification. Using 14 years […]
In the German multicenter study of 5,521 patients with colorectal cancer (CRC), the apparent survival advantage associated with overweight and obesity at diagnosis was largely explained by cancer-associated weight loss before diagnosis. Compared with patients with normal weight, those who were overweight had modestly better overall survival (HR, 0.89), whereas […]
In a US longitudinal multi-omic study of 1,154 hospitalized patients with COVID-19 from the IMPACC cohort, significant reactivation of Herpesviridae and Anelloviridae was common during acute COVID-19, with virus-specific temporal patterns and associations with disease severity, host immune responses, and clinical outcomes. Chronic viral infections are ubiquitous in humans, and […]
Accelerated biological aging was associated with a higher risk of early-onset solid cancers in young adults, particularly lung, gastrointestinal, and uterine cancers, suggesting that biological aging may help explain the rising incidence of cancer in recent generations. In a study of 154,169 young adults from the UK Biobank, systemic biological […]
A systematic review and network meta-analysis of 262 randomized trials involving 99,791 participants found that anti-obesity medications vary substantially in both effectiveness and safety, with greater weight loss generally accompanied by higher rates of adverse events and treatment discontinuation. At one year, tirzepatide and cagrilintide-semaglutide (CagriSema) produced the greatest confirmed […]
Baseline use of proton pump inhibitors (PPIs) and, to a lesser extent, antibiotics was associated with poorer outcomes in patients with unresectable stage III non-small cell lung cancer (NSCLC) treated with durvalumab after chemoradiotherapy, suggesting these medications may reduce the benefit of immunotherapy. This post-hoc analysis of the phase 3 […]
A nationwide Danish study found that recent use of several progestogen-containing contraceptives—including cyproterone, desogestrel, drospirenone, gestodene, levonorgestrel, injectable medroxyprogesterone, and high-dose levonorgestrel intrauterine devices (IUDs)—was associated with an increased risk of meningioma, with injectable medroxyprogesterone showing the strongest association. Researchers analyzed nationwide health registry data from approximately 3 million women […]
Higher vitamin A levels were associated with better lung function in children and adults with asthma, while adequate vitamin D levels were linked to better lung function and slower epigenetic aging in adults. Researchers analyzed two asthma cohorts involving 1,165 children and 1,041 adults, measuring vitamin A and D levels […]
Higher coffee consumption was associated with substantially lower risks of cirrhosis, liver cancer, and liver-related death, while also showing favorable liver imaging and proteomic profiles in a prospective study of nearly 355,000 participants from the UK Biobank. During a median follow-up of 13 years, individuals who drank at least five […]