Alcohol consumption was independently associated with a substantially higher risk of hepatocellular carcinoma (HCC) among patients with chronic hepatitis B (CHB), regardless of cirrhosis status. In this study of 1,010 CHB patients followed for a total of 3,684 person-years, 129 (12.77%) developed HCC. Compared with patients without HCC, those who […]
Consuming sweets and simple sugars during antibiotic treatment was associated with greater gut microbiome disruption, including reduced microbial diversity and expansion of the pathobiont Enterococcus. In this study, researchers precisely tracked 9,419 meals consumed by 173 patients undergoing haematopoietic cell transplantation and analyzed longitudinal microbiome changes in 158 patients with […]
A systematic review of 82 studies found that stroke related to cancer-associated coagulopathy (CAC) is a distinct, often underrecognized condition characterized by early occurrence, frequent recurrence, characteristic imaging findings, and high mortality. CAC-related stroke occurs predominantly within six months of cancer diagnosis and is strongly associated with advanced or metastatic […]
In two UK cohorts including 977,282 adults, drinking beverages at a “very hot” temperature was associated with more than a threefold higher risk of esophageal squamous cell carcinoma (SCC), while drinking 6 or more hot beverages per day was associated with a 71% higher SCC risk. Over 11–14 years of […]
In a UK prospective cohort of 502,188 adults followed for a median of 13.6 years, mortality was lowest at hemoglobin concentrations approximately 1–3 g/dL above the current WHO anemia thresholds, while both lower and higher concentrations were associated with increased mortality. The association between hemoglobin and all-cause mortality was U-shaped: […]
Regular smoking was associated with a lower risk of Parkinson disease (PD), and among people who never smoked, higher levels of exhaled carbon monoxide (CO) were associated with a lower risk of PD in a broadly dose-dependent manner. This nationwide prospective cohort study included 512,724 adults aged 30–79 years from […]
Alcohol-attributable cancer deaths in the USA doubled from 11,361 in 1990 to 23,126 in 2023, with a disproportionate burden among men and adults aged 55 years and older. This population-based observational trend analysis used Global Burden of Disease data to examine age-standardized mortality rates (ASMRs) attributable to heavy alcohol use […]
Higher periconception parental vitamin B12 levels and higher postconception maternal red blood cell (RBC) folate levels were associated with lower predicted prevalences of birth defects in a prospective cohort study from Shanghai, China. The study included 3032 couples with biomarker measurements obtained within 4 months before conception and 17,765 women […]
The US updated evidence-based recommendations provide clinicians with comprehensive guidance on when to initiate pharmacologic migraine prevention, how to select an appropriate preventive medication, and how to monitor treatment effectiveness, adverse effects, and medication discontinuation in adults. Developed by a multidisciplinary panel using a systematic review of studies published through […]
In a US retrospective observational cohort study of 623 young adults, significant infradian (multiday) heart rate rhythms were detected in 70% of participants, with 36% showing two or more distinct rhythms. Using up to four years of wearable and questionnaire data from the University of Notre Dame’s NetHealth project, researchers […]