In a Chinese phase 3 trial (LungTIME-C01) involving 210 patients with advanced non-small cell lung cancer, administering anti-PD-1 immunotherapy before 3:00 PM nearly doubled progression-free survival (11.3 vs. 5.7 months) and significantly improved overall survival (28.0 vs. 16.8 months) compared to later infusions. This early time-of-day treatment was linked to […]
A large natural experiment study in Ontario, Canada, found that receiving the live attenuated herpes zoster vaccine significantly reduced the risk of a new dementia diagnosis by approximately 18% in adults aged 70 and older, providing the strongest evidence to date for a potential causal protective effect. The research leveraged […]
Long-term and intensive night shift work was associated with a significantly higher risk of cardiovascular–kidney–metabolic (CKM) disease in a large UK Biobank cohort, with the strongest effects seen among individuals who slept six hours or less per night. Among 96,365 participants followed through 2022, those with more than 20 years […]
Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]
Even moderate alcohol consumption was consistently linked to a higher risk of multiple cancers, with clear dose–response relationships showing that risk rises with greater frequency and quantity of drinking. In this systematic review of 62 U.S.-based studies, alcohol use was most strongly associated with increased risks of breast, colorectal, and […]
Adjunct low-dose, short-course corticosteroids probably reduce short-term mortality in adults with severe pneumonia or acute respiratory distress syndrome (ARDS), according to a review of 20 randomized trials involving 3459 participants. Drawing from major medical databases through September 2025, the analysis found that corticosteroids (3 mg/kg of body weight per day […]
Better mental wellbeing substantially reduces the risk of developing irritable bowel syndrome (IBS), with effects that are independent of genetic predisposition and partly mediated through lower depression and anxiety. In this prospective UK Biobank cohort of 75,842 IBS-free participants followed for 12.4 years, 1,400 incident IBS cases occurred, and higher […]
Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]
Clonal hematopoiesis of indeterminate potential (CHIP), particularly non-DNMT3A CHIP subtypes, is an independent risk factor for incident heart failure (HF) and may represent a novel therapeutic target. In a UK Biobank cohort of 417,616 adults (mean age, 56.1 years; 56.2% women) without prior HF or major comorbidities, 7,183 participants (1.7%) […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]