Mortality

Long-Term Outcomes of Invasive vs Conservative Management in Stable Coronary Disease: Consistent Evidence From Extended Follow-Up Trials

This entry was posted in Cardiovascular Diseases and tagged Conservative Invasive Mortality Myocardial Infarction Stable Coronary Disease Treatment on

Extended follow-up of three major trials consistently shows that an initial invasive strategy does not improve long-term survival or reduce myocardial infarction (MI) compared with initial conservative management in patients with stable coronary disease. In the COURAGE trial’s extended observational analysis of 959 US veterans (median follow-up 15 years, maximum […]

Low Protein Intake Linked to Higher Risks of Kidney Failure and Death in CKD

This entry was posted in Uncategorized and tagged CKD Kidney Failure Mortality Protein Intake on

A prospective cohort study of 1,861 patients with nondialysis-dependent chronic kidney disease (CKD) in South Korea found that very low protein intake was associated with higher risks of kidney failure requiring replacement therapy (KFRT) and all-cause mortality, without a significant association with major adverse cardiovascular events. Over a median follow-up […]

Exercise-Based Cardiac Rehabilitation Improves Outcomes in Coronary Heart Disease

This entry was posted in Cardiovascular Diseases and tagged CHD Exercise Based Cardiac Rehabilitation Mortality Outcomes on

A 2026 Cochrane systematic review and meta-analysis of 107 randomized trials involving 26,886 adults with coronary heart disease (CHD) found that exercise-based cardiac rehabilitation (CR), compared with no structured exercise, reduces myocardial infarction (MI) and all-cause hospitalizations, likely provides a small reduction in mortality, and improves health-related quality of life […]

Hemoglobin Levels and Mortality

This entry was posted in Uncategorized and tagged Age Hemoglobin Level Mortality Sex on

In a UK prospective cohort of 502,188 adults followed for a median of 13.6 years, mortality was lowest at hemoglobin concentrations approximately 1–3 g/dL above the current WHO anemia thresholds, while both lower and higher concentrations were associated with increased mortality. The association between hemoglobin and all-cause mortality was U-shaped: […]

Alcohol-Attributable Cancer Mortality Doubled in the USA Since 1990

This entry was posted in Uncategorized and tagged Alcohol Intake Cancer Mortality on

Alcohol-attributable cancer deaths in the USA doubled from 11,361 in 1990 to 23,126 in 2023, with a disproportionate burden among men and adults aged 55 years and older. This population-based observational trend analysis used Global Burden of Disease data to examine age-standardized mortality rates (ASMRs) attributable to heavy alcohol use […]

BMI and Waist Circumference Jointly Predict Mortality Risk in Older Adults

This entry was posted in Uncategorized and tagged BMI Mortality Old Adults Sex-Specific Waist Circumference on

In US adults aged ≥65 years, overweight and class I–II obesity were associated with lower all-cause mortality risk, whereas high waist circumference and being underweight were associated with higher mortality risk, highlighting the importance of central adiposity and the limitations of BMI alone for mortality risk stratification. Using 14 years […]

Longitudinal Heart Stress Status Predicts CVD and Mortality in Older Adults

This entry was posted in Cardiovascular Diseases and tagged CVD Heart Stress Longitudinal Mortality NT-proBNP Old Adults on

In community-dwelling older adults without prior cardiovascular disease (CVD), new or persistent heart stress (HS)—defined by elevated NT-proBNP concentrations over 3 years—was associated with substantially higher risks of CVD and all-cause mortality, whereas HS remission was associated with risks similar to those of individuals who remained HS-free. In the observational […]

The Obesity Paradox in Colorectal Cancer May Reflect Prediagnostic Weight Loss

This entry was posted in Uncategorized and tagged Cancer-Associated Weight Loss Colorectal Cancer Mortality Obesity Paradox on

In the German multicenter study of 5,521 patients with colorectal cancer (CRC), the apparent survival advantage associated with overweight and obesity at diagnosis was largely explained by cancer-associated weight loss before diagnosis. Compared with patients with normal weight, those who were overweight had modestly better overall survival (HR, 0.89), whereas […]

Left Ventricular Size and Mortality Risk in Heart Failure

This entry was posted in Cardiovascular Diseases and tagged Heart Failure Left Ventricular Size Mortality on

A Chinese nationwide study of 273,921 patients hospitalized with heart failure (HF) found a U-shaped association between left ventricular end-diastolic diameter (LVEDD) and mortality, with both abnormally small and abnormally large left ventricles independently associated with higher all-cause mortality. Using data from the Chinese Cardiovascular Association Database–Heart Failure Center Registry, […]

Midlife Vascular Health Linked to Up to 12.6 More Dementia-Free Years

This entry was posted in Cardiovascular Diseases Mental Disorders and tagged Dementia Midlife Mortality Risk Factors on

Maintaining optimal vascular health in midlife was associated with up to 12.6 additional years of life free from dementia between ages 55 and 95. The prospective analysis of 12,409 participants from the US Atherosclerosis Risk in Communities (ARIC) study followed for a median of 26.3 years, evaluated three major midlife […]