CHD

Ziltivekimab and Pelacarsen Show No Clinical Benefit Despite Effective Biomarker Lowering

This entry was posted in Cardiovascular Diseases and tagged CHD Efficacy Pelacarsen Safety Ziltivekimab on

Two randomized, placebo-controlled trials of targeted therapies—ziltivekimab, a monoclonal antibody neutralizing interleukin-6, and pelacarsen, an antisense oligonucleotide lowering lipoprotein(a)—both failed to reduce major adverse cardiovascular events despite effectively lowering their respective biomarkers. In the ziltivekimab trial, 6,376 adults with established atherosclerotic cardiovascular disease, chronic kidney disease, and cardiovascular inflammation (high-sensitivity […]

CCTA-Guided PCI Noninferior to IVUS-Guided PCI

This entry was posted in Cardiovascular Diseases and tagged CCTA CHD IVUS PCI on

In a randomized, open-label, noninferiority trial, a coronary computed tomographic angiography (CCTA)–guided percutaneous coronary intervention (PCI) strategy was noninferior to intravascular ultrasound (IVUS)–guided PCI with respect to target-vessel failure at 12 months; among 1,105 randomized patients, target-vessel failure occurred in 4.1% of the CCTA-guided group versus 4.6% of the IVUS-guided […]

Exercise-Based Cardiac Rehabilitation Improves Outcomes in Coronary Heart Disease

This entry was posted in Cardiovascular Diseases and tagged CHD Exercise Based Cardiac Rehabilitation Mortality Outcomes on

A 2026 Cochrane systematic review and meta-analysis of 107 randomized trials involving 26,886 adults with coronary heart disease (CHD) found that exercise-based cardiac rehabilitation (CR), compared with no structured exercise, reduces myocardial infarction (MI) and all-cause hospitalizations, likely provides a small reduction in mortality, and improves health-related quality of life […]

Incidental Coronary Calcium on Routine Chest CT Predicts Future Cardiovascular Risk as Well as Dedicated Heart Scans

This entry was posted in Cardiovascular Diseases and tagged CAC CHD CT Scan CVD Non-Gated Risk on

Incidental coronary artery calcium (CAC) identified on routine nongated chest CT scans predicts future coronary heart disease (CHD) and cardiovascular disease (CVD) events with prognostic performance comparable to dedicated gated cardiac CT, supporting its incorporation into routine clinical practice for cardiovascular risk assessment. This study included 2,472 participants from the […]

Modifiable Cardiovascular Risk Factors Linked to More Vulnerable Coronary Plaques

This entry was posted in Cardiovascular Diseases and tagged Atherosclerosis; Risk Factors CHD Coronary Plaques on

The burden of modifiable cardiovascular risk factors—not just the total number of risk factors—is strongly associated with greater coronary plaque vulnerability, suggesting that controlling these risk factors may help reduce the development of high-risk plaques. In this US study of 131 patients who underwent 3-vessel optical coherence tomography imaging, researchers […]

Viral Infections Increase CHD Risk

This entry was posted in Cardiovascular Diseases Uncategorized and tagged CHD Risk Viral Infections on

A systematic review and meta‐analysis suggests that influenza, SARS‐CoV‐2, HIV, hepatitis C virus, and herpes zoster are all associated with an increased risk of major cardiovascular events. The analysis included 155 studies, viral infections were consistently linked to higher rates of coronary heart disease (CHD) and stroke. HIV infection was […]

Geographical Variation in Lipoprotein (a) Levels Among CHD Patients

This entry was posted in Cardiovascular Diseases and tagged CHD Lipoprotein (a) Variation on

A global study suggested that most patients with coronary heart disease (CHD) have Lipoprotein (a) [Lp(a)] levels below risk-enhancing thresholds with wide geographical variations. The study assessed Lp(a) levels in 3,928 CHD patients across 13 countries in six World Health Organization regions. Median Lp(a) level was 32 nmol/L, with 17.6% […]

Mediterranean Diet May Slow Atherosclerosis Progression and Prevent CHD

This entry was posted in Cardiovascular Diseases and tagged CHD Diet Prevention on

A Spanish secondary prevention study suggested that Mediterranean diet might reduce neutrophil levels and slow the progression of atherosclerosis and was superior to a low-fat diet in preventing major events of coronary heart disease (CHD). A total of 1002 CHD patients were randomly assigned to follow either a low-fat diet […]