In patients with prior intracerebral hemorrhage, adding a single pill combining three low-dose antihypertensive agents to standard care significantly reduced recurrent stroke and major cardiovascular events compared with placebo. In this multinational, double-blind, randomized controlled trial of 1,670 clinically stable patients with baseline systolic blood pressure (BP) of 130–160 mm […]
A prospective US cohort study leveraging data from 3,477 participants (mean age 74.8 years; 61.5% female) in the Atherosclerosis Risk in Communities (ARIC) study has found that higher aldosterone-renin ratio (ARR) is independently associated with increased cardiovascular risk over nearly a decade of follow-up. Researchers measured serum aldosterone and renin […]
Adding carotid-artery stenting—but not carotid endarterectomy—to intensive medical management reduced the risk of stroke or death in patients with high-grade asymptomatic carotid stenosis. In two parallel, observer-blinded trials including more than 2,400 participants with ≥70% stenosis, the 4-year incidence of the primary composite outcome (any stroke or death from randomization […]
An international case–control study suggested that vascular risk factors influence stroke risk differently across age groups. The study enrolled age- and sex-matched cases of the first acute stroke and controls across 32 countries between Jan 11, 2007, and Aug 8, 2015. Participants underwent clinical assessments and provided blood and urine […]
A systematic review and prospective individual participant data meta-analysis of randomized controlled trials supports early direct oral anticoagulants (DOACs) initiation within 4 days for patients with acute ischemic stroke and atrial fibrillation to reduce the risk of recurrent stroke without increasing bleeding risk. The analysis included four trials met inclusion […]
A study revealed that stroke remains a major global health challenge, influenced by numerous risk factors that vary across regions and populations. The study analyzed stroke-related mortality from 1990 to 2021 using Global Burden of Disease 2021 data, focusing on three primary stroke subtypes: ischemic stroke, intracerebral hemorrhage, and subarachnoid […]
A prespecified subgroup analysis of a Chinese randomized clinical trial suggested that salt substitution significantly reduced the risks of stroke recurrence and death. The analysis included 15 249 patients with stroke (mean age, 64.1 years; female 45.9%; male 54.1%) from an open-label, cluster randomized clinical trial. Patients were assigned to […]
A double-blind, placebo-controlled, multicenter, parallel-group, phase 3 randomized clinical trial in China revealed that sublingual edaravone dexborneol improved functional outcome at 90 days compared to placebo in patients with acute ischemic stroke (AIS). Within 48 hours of diagnosis, 914 AIS patients (median age, 64.0 [56.0-70.0] years; male 66.5%) were randomly […]
A meta-analysis and a meta-regression of randomized clinical trials suggested that more intensive differential blood pressure (BP)–lowering may be beneficial for prevention of recurrent stroke and major cardiovascular events. The analysis included 10 randomized clinical trials comprising 40 710 patients (women 34%; mean age 65 years) with stroke or transient ischemic […]
Three trials have shown remarkable benefits of thrombectomy in patients with large ischemic strokes in countries with different medical systems. The benefits of thrombectomy were consistent across age, degree of neurologic deficit, imaging characteristics, time of treatment, and geographic location. Thrombectomy resulted in significantly better functional outcomes than medical care […]