An open-label, blinded-endpoint, randomized controlled trial in China suggested that intensive control of systolic blood pressure (SBP) to lower than 120 mm Hg should be avoided to prevent compromising the functional recovery of patients who have received endovascular thrombectomy due to intracranial large-vessel occlusion. The trial enrolled 821 patients (aged […]
A multicenter, open-label, blinded–end point, randomized clinical trial in China showed that remote ischemic conditioning (RIC) was associated with better neurologic function in patients with acute moderate ischemic stroke. The trial randomly assigned 1893 patients (mean age, 65 years; women 34.1%; 93.8% completed the trial) within 48 hours after symptom […]
A US cohort study suggested that more active time, especially at moderate intensities, and less sedentary time, particularly in longer bouts, may reduce the risk of stroke. The study included 7607 participants (mean age 63.4 years; 54.5% female, 31.6% Black, and 68.4% White), including 54.7% of them resided in the […]
The 2021 secondary stroke prevention guideline from the American Heart Association/American Stroke Association: 1. Recommendations for the diagnostic workup to define ischemic stroke etiology. 2. Management of vascular risk factors remains extremely important, including (but not limited to) diabetes, smoking cessation, lipids, and especially hypertension. 3. Lifestyle factors: Low-salt and […]
Ten metabolites from seven prospective cohort studies were found to be associated with risk of stroke. The studies included 1,791 incident stroke events among 38,797 participants. Independent of traditional risk factors including hypertension, diabetes, smoking, and body mass index, amino acid histidine (hazard ratio [HR] per standard deviation [SD] = […]
A prospective cohort study in England found that the prevalence ofasymptomatic intracranial stenosis (ICS) increased with age in patients with transient ischemic attack (TIA) and minor stroke, but did not increase the short- or medium-term risk of distal recurrent ischemic stroke in patients receiving standard medical treatment. The study included […]
A Chinese prospective cohort study concluded that long sleep duration, long midday napping, and poor sleep quality were independently and jointly associated with higher risks of incident stroke. Persistently long sleep duration or switch from average to long sleep duration increased the risk of stroke. The study included 31,750 retirees […]
A Chinese genetic epidemiological analyses revealed that alcohol intake uniformly increases blood pressure (BP) and stroke, indicating that the apparently protective effects of moderate alcohol intake against stroke suggested by conventional epidemiological analyses are largely non-causal. The study enrolled 512 715 adults between June 25, 2004, and July 15, 2008, from […]
An UK prospective population based cohort study found that genetic and lifestyle factors were independently associated with risk of incident stroke. The study recruited 306 473 men and women, aged 40-73 years, between 2006 and 2010. During a median follow-up of 7.1 years (2 138 443 person years), 2077 incident strokes (1541 ischemic […]