In patients with type 2 diabetes (T2D) and high cardiovascular risk, targeting a systolic blood pressure (BP) of less than 120 mm Hg did not significantly reduce major cardiovascular events compared with a target of less than 140 mm Hg, according to a multicenter, open-label, randomized trial conducted in Brazil. […]
A meta-analysis of 85 randomized clinical trials involving 70,543 participants found that sodium-glucose cotransporter 2 (SGLT2) inhibitors were associated with small but statistically significant increases in hemoglobin and hematocrit levels compared with control treatments, although the clinical significance of these changes remains unclear. The trials had a median follow-up of […]
A 16-week low-fat vegan diet was associated with significant reductions in body weight, visceral fat, liver fat, and advanced glycation end products (AGEs), alongside improved insulin sensitivity and beta-cell function in adults with type 2 diabetes (T2D). In this US study of 25 participants, mean body weight decreased by 6.0 […]
A healthy, balanced dietary pattern—not an emphasis on individual nutrients or foods—is central to preventing and managing cardiovascular and cardiometabolic disease, according to a new American College of Cardiology Scientific Statement. The statement reviews evidence on macronutrients, micronutrients, dietary patterns, ultra-processed foods, and emerging nutrition-based interventions, emphasizing that heart-healthy eating […]
Moderate consumption of naturally caffeinated beverages, particularly coffee, is generally associated with a lower risk of several cardiovascular diseases, whereas high doses of caffeine—such as those found in many energy drinks—may increase cardiovascular risk. Caffeine is one of the world’s most widely consumed psychoactive substances, and its cardiovascular effects vary […]
A Danish randomized crossover trial found that a single session of high-intensity interval exercise (HIIE) significantly reduced immediate energy intake and appetite in adults with overweight or obesity, without increasing food intake over the following 24 hours, while the time of day had only modest effects that differed by type […]
Long-term follow-up of two randomized lifestyle intervention trials found that reducing visceral fat—not simply losing weight—was strongly associated with sustained cardiometabolic health benefits, and every 10% reduction in visceral fat lowered the future risk of type 2 diabetes by 28%. Researchers followed 366 participants from the 18-month CENTRAL and DIRECT-PLUS […]
Blood pressure (BP)-lowering treatment significantly reduces the risk of major cardiovascular events in individuals with chronic kidney disease (CKD) across all stages, with effects comparable to those without CKD, although benefits are diminished in patients with coexisting diabetes. This one-stage individual-participant meta-analysis included 52 randomized controlled trials, of which 46 […]
A rigorous cohort study utilizing Taiwan’s National Health Insurance Database provides robust evidence that SGLT2 inhibitors offer superior multi-organ protection for the complex population of patients with both type 2 diabetes and liver cirrhosis. Among 24,259 adults (average age 64.7 years; 33.9% female) followed for a median of 2.3 years, […]
A US randomized, 4-period crossover feeding study revealed that sodium reduction, especially when combined with a Dietary Approaches to Stop Hypertension (DASH)-style diet optimized for diabetes (DASH4D), can significantly lower blood pressure (BP) in patients with type 2 diabetes (T2D) and high BP, even among those already using multiple antihypertensive […]