Subjective olfactory impairment (self-reported smell loss) is consistently associated with a higher likelihood of depression, whereas objectively measured olfactory impairment is more strongly linked to depression in older adults and individuals with complete smell loss. This systematic review and meta-analysis included 23 population-based studies representing 17 independent cohorts and 187,056 […]
A comprehensive systematic review and meta-analysis involving 69 randomized controlled trials and 153,902 adults found that calcium supplements, vitamin D supplements, or their combination offer little to no clinically meaningful benefit in preventing fractures or falls in adults not taking osteoporosis medications. Most participants were community-dwelling individuals (87%) and were […]
A longitudinal cohort study suggested that childhood risk factors contributed both directly and indirectly to adult cardiovascular disease (CVD), and that intervening in the risk factors in childhood should be emphasized to reduce the risk of CVD later in life, especially body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). […]
A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]