A natural experiment study investigated whether exposure to sugar rationing during early life was associated with reduced risk of cardiovascular disease (CVD) in adulthood. Using data from 63,433 UK Biobank participants born between 1951 and 1956, researchers compared individuals exposed to sugar rationing in utero or early childhood with those […]
Data from the Global Burden of Disease (GBD) 2023 study showed that cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, with their burden continuing to rise since 1990 due to population growth, aging, and changing exposures to harmful risk factors. The GBD study covered 204 countries […]
A global analysis of over 2 million individuals from 133 cohorts across 39 countries found that five classic risk factors—high blood pressure, hyperlipidemia, underweight/overweight or obesity, diabetes, and smoking—account for about half of the global cardiovascular disease (CVD) burden. Researchers estimated lifetime risks and outcomes up to age 90 based […]
A UK longitudinal associations study revealed that hyperlipidemias and inflammation independently and together raise the risk of serious cardiovascular diseases (CVD). The risk is more closely tied to the actual blood levels of these markers than to the use or not of cholesterol-lowering medication. Data were from 322,922 participants (55.9% […]
Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular disease (CVD) risk and improving longevity. The first study analyzed data from over 24,000 middle-aged and older non-exercisers in the UK Biobank, examining the effects of incidental physical activity (IPA)—unstructured daily movement outside formal exercise—on […]
A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor agonists (GLP1-RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) were associated with reduced rates of 3-point major adverse cardiovascular events (3P-MACE) and hospitalization for heart failure (HHF) compared to dipeptidyl peptidase 4 inhibitors (DPP-4is). Compared to […]
A UK device-based prospective study suggested that irregular sleep was associated with higher risk of major adverse cardiovascular events (MACE), regardless of whether individuals met sleep duration recommendations or not. The study included 72 269 individuals aged 40–79 years and followed for 7.8 years, without a previous history of MACE and […]
A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels among initially healthy U.S. women predicted incident cardiovascular events over a 30-year period. High-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels were measured at baseline in 27,939 healthy U.S. women with mean age of 54.7 […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]
A multilipid score (MLS), reflecting the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations, was associated with significantly lower risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). The MLS was based on lipidomics data from a randomized controlled dietary intervention trial, replacing specific […]