A Japanese nationwide cohort study suggested that a diverse array of electrocardiogram (ECG) abnormalities was associated with an increased mortality and cardiovascular disease (CVD). The study included data of 3 698 429 working individuals (mean age, 47.1 years; 66.6% male) from April 1, 2015, to March 31, 2022, 16.8% had 1 minor […]
A longitudinal cohort study suggested that childhood risk factors contributed both directly and indirectly to adult cardiovascular disease (CVD), and that intervening in the risk factors in childhood should be emphasized to reduce the risk of CVD later in life, especially body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). […]
A UK prospective cohort study suggested that plant sourced non ultra-processed foods (UPF) linked to a lower risk of cardiovascular disease (CVD), while plant sourced UPF linked to a higher CVD risk. Data were from the UK Biobank participants (40–69 y, n = 126,842, median follow-up 9 y) who completed at least two 24-h […]
A US cohort study suggested that physical activity (PA) appears to reduce cardiovascular disease (CVD) risk in part by acting through the brain’s stress-related activity. The study included a total of 50,359 adults (median age 60 years; 40.1% male). Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical […]
The post hoc analysis of postintervention follow-up of calcium and vitamin D (CaD) supplements suggested reduced cancer mortality and increased cardiovascular disease (CVD) mortality. The multicenter trial across the US included 36 282 postmenopausal women randomized 1:1 to 1000 mg of calcium carbonate (400 mg of elemental calcium) with 400 IU […]
A prospective dose–response analysis of total daily steps with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels revealed that any number of daily steps above 2200 steps/day was associated with lower mortality and incident CVD risk, with 9000–10 500 steps/day being associated with the lowest mortality risk independent […]
Studies suggested that terminal breakdown products of excess niacin (vitamin B3 or nicotinic acid) are associated with residual cardiovascular disease (CVD) risk and provided a possible explanation for the ‘niacin paradox’—the observation that the LDL lowering induced by niacin fails to achieve the expected reduction in CVD risks. Untargeted metabolomics […]
The analysis of a UK cohort study suggests that a weekend warrior pattern of physical activity was associated with similarly lower risks of cardiovascular diseases (CVD) to regular activity. A total of 89 573 individuals (mean age, 62 years; 56% women) who underwent accelerometry were included. When stratified at the threshold […]
A cross-sectional analysis suggested that a multivariable model of clinical and genetic risk factors explains only 36% of the likelihood of family history of heart disease (FHHD), with most of the risk of a FHHD unexplained. The analysis included 166,714 UK Biobank participants with 43.2% reported a FHHD. In the […]
A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]