Effectiveness


Pulsed Field Ablation Proven Superior to Sham Procedure for Symptomatic AF

A sham-controlled randomized trial demonstrated that pulsed field ablation (PFA) markedly reduced atrial fibrillation (AF) recurrence and burden while significantly improving quality of life and psychological distress compared with a sham procedure in highly symptomatic AF patients. In this single-blind study, 60 patients with severe AF-related quality-of-life impairment were randomized […]


Smartphone-Based Digital CBT Produces Large and Sustained Benefits for GAD

In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]


Updated Evidence Supports Current Vaccines Safety and Effectiveness

Ongoing peer-reviewed evidence supports the safety and effectiveness of vaccines against Covid-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. In a systematic review of 511 studies out of 17,263 identified references, Covid-19 mRNA vaccines targeting the XBB.1.5 subvariant showed pooled effectiveness against hospitalization of 46% from cohort […]