Adding carotid-artery stenting—but not carotid endarterectomy—to intensive medical management reduced the risk of stroke or death in patients with high-grade asymptomatic carotid stenosis. In two parallel, observer-blinded trials including more than 2,400 participants with ≥70% stenosis, the 4-year incidence of the primary composite outcome (any stroke or death from randomization […]
Low-dose colchicine reduces myocardial infarction and stroke in people with cardiovascular disease (CVD) without increasing serious adverse events, although it raises the risk of mild gastrointestinal symptoms and shows no clear effect on mortality or revascularization. In an updated Cochrane review of 12 randomized controlled trials including 22,983 participants followed […]
Endotyping-informed therapy guided by adenosine stress cardiovascular MRI revised diagnoses in over half of patients with chest pain and unobstructed coronary arteries and significantly improved angina and quality of life at 12 months. In this prospective, multicenter, randomized controlled trial of 250 patients (mean age 63.3 years; 50.4% female) in […]
In patients with ST-segment elevation myocardial infarction (STEMI), early subcutaneous administration of zalunfiban significantly improved coronary artery patency and reduced the risk of adverse 30-day clinical outcomes without increasing severe bleeding. In an international, double-blind, placebo-controlled trial of 2,467 patients randomly assigned to receive zalunfiban (0.11 mg/kg or 0.13 mg/kg) […]
Clonal hematopoiesis of indeterminate potential (CHIP), particularly non-DNMT3A CHIP subtypes, is an independent risk factor for incident heart failure (HF) and may represent a novel therapeutic target. In a UK Biobank cohort of 417,616 adults (mean age, 56.1 years; 56.2% women) without prior HF or major comorbidities, 7,183 participants (1.7%) […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]
Intracoronary infusion of Wharton’s jelly–derived mesenchymal stem cells after acute myocardial infarction (AMI) significantly reduced the risk of developing heart failure (HF) and related adverse cardiovascular events, suggesting its potential as a valuable adjunctive therapy. In a Iranian phase 3 randomized clinical trial involving 420 patients with a first ST-segment […]
A systematic review and meta‐analysis suggests that influenza, SARS‐CoV‐2, HIV, hepatitis C virus, and herpes zoster are all associated with an increased risk of major cardiovascular events. The analysis included 155 studies, viral infections were consistently linked to higher rates of coronary heart disease (CHD) and stroke. HIV infection was […]
A placebo-controlled, n-of-1 study suggested that coronary collateralization may lessen the intensity of ischemic chest pain. The study included 51 participants with stable single-vessel coronary artery disease and angina. After discontinuing antianginal medications, participants recorded daily angina using a smartphone app for 14 days before undergoing invasive pressure wire studies […]
A natural experiment study investigated whether exposure to sugar rationing during early life was associated with reduced risk of cardiovascular disease (CVD) in adulthood. Using data from 63,433 UK Biobank participants born between 1951 and 1956, researchers compared individuals exposed to sugar rationing in utero or early childhood with those […]