Early-life sugar restriction during pregnancy and infancy was associated with a 34% lower risk of early-onset cancer (diagnosed by age 50), although it was not associated with a significant reduction in cancer-specific mortality. Using a natural experiment created by the end of UK sugar rationing, researchers analyzed 63,819 UK Biobank […]
Higher levels of physical activity were associated with lower risks of all-cause dementia, Alzheimer’s disease, and vascular dementia, but the associations differed substantially by physical activity domain. In this systematic review and meta-analysis, 74 cohort and case–control studies involving 4,227,297 participants were analyzed, with a median follow-up of 10.0 years. […]
In US adults aged ≥65 years, overweight and class I–II obesity were associated with lower all-cause mortality risk, whereas high waist circumference and being underweight were associated with higher mortality risk, highlighting the importance of central adiposity and the limitations of BMI alone for mortality risk stratification. Using 14 years […]
In community-dwelling older adults without prior cardiovascular disease (CVD), new or persistent heart stress (HS)—defined by elevated NT-proBNP concentrations over 3 years—was associated with substantially higher risks of CVD and all-cause mortality, whereas HS remission was associated with risks similar to those of individuals who remained HS-free. In the observational […]
In the German multicenter study of 5,521 patients with colorectal cancer (CRC), the apparent survival advantage associated with overweight and obesity at diagnosis was largely explained by cancer-associated weight loss before diagnosis. Compared with patients with normal weight, those who were overweight had modestly better overall survival (HR, 0.89), whereas […]
In adults aged 75 years or older without a history of atherosclerotic cardiovascular disease (ASCVD) who were taking statins for primary prevention, discontinuing statin therapy was non-inferior to continuing treatment with respect to 3-year all-cause mortality. In the French multicentre, open-label, phase 3 randomised controlled trial, 1,180 participants were assigned […]
A Chinese nationwide study of 273,921 patients hospitalized with heart failure (HF) found a U-shaped association between left ventricular end-diastolic diameter (LVEDD) and mortality, with both abnormally small and abnormally large left ventricles independently associated with higher all-cause mortality. Using data from the Chinese Cardiovascular Association Database–Heart Failure Center Registry, […]
A systematic review and meta-analysis found that intravenous thrombolysis (IVT) given 4.5 hours or more after acute ischemic stroke onset was associated with better functional outcomes, although it increased the risk of symptomatic intracerebral hemorrhage (ICH). The analysis included 14 randomized clinical trials involving 4,174 patients comparing IVT with placebo […]
Waist circumference (WC) and waist-to-hip ratio (WHR) identified important differences in cardiovascular disease (CVD) risk that were not captured by conventional BMI categories, suggesting that central adiposity can reclassify CVD risk across normal weight, overweight, and obesity and provide additional diagnostic and prognostic information. The US Cross-Cohort Collaboration study included […]
In a US longitudinal multi-omic study of 1,154 hospitalized patients with COVID-19 from the IMPACC cohort, significant reactivation of Herpesviridae and Anelloviridae was common during acute COVID-19, with virus-specific temporal patterns and associations with disease severity, host immune responses, and clinical outcomes. Chronic viral infections are ubiquitous in humans, and […]