Comparison; Efficacy; Acceptability; Antidepressants;

Antidepressants Differ in Efficacy and Acceptability in Long-Term Treatment of Major Depressive Disorder

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Escitalopram, duloxetine, and agomelatine achieved higher sustained response rates than fluoxetine, while escitalopram and duloxetine also showed lower all-cause discontinuation, according to a systematic review and network meta-analysis of 115 double-blind randomised controlled trials (30,428 participants) comparing 21 antidepressants for long-term (>12 weeks) treatment of adult unipolar major depressive disorder. […]

Comparative Efficacy and Acceptability of Antidepressants

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A systematic review and network meta-analysis concluded that all 21 antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy (response rate) and acceptability (treatment discontinuations […]