Antidepressants Differ in Efficacy and Acceptability in Long-Term Treatment of Major Depressive Disorder
Escitalopram, duloxetine, and agomelatine achieved higher sustained response rates than fluoxetine, while escitalopram and duloxetine also showed lower all-cause discontinuation, according to a systematic review and network meta-analysis of 115 double-blind randomised controlled trials (30,428 participants) comparing 21 antidepressants for long-term (>12 weeks) treatment of adult unipolar major depressive disorder. […]