Blood pressure (BP)-lowering treatment significantly reduces the risk of major cardiovascular events in individuals with chronic kidney disease (CKD) across all stages, with effects comparable to those without CKD, although benefits are diminished in patients with coexisting diabetes. This one-stage individual-participant meta-analysis included 52 randomized controlled trials, of which 46 […]
A new clinical practice guideline from the American Academy of Sleep Medicine indicates that cognitive behavioral therapy for insomnia (CBT-I) alone remains the most effective first-line treatment for chronic insomnia, while adding medication may offer modest benefits for select outcomes such as total sleep time. The guideline is supported by […]
While myocardial infarction (MI) accounts for a substantial proportion of sudden cardiac deaths (SCDs), most arrhythmic SCDs occur in individuals without previously diagnosed risk factors, often due to occult cardiac disease such as silent MI or dilated cardiomyopathy. In the 12-year US countywide POST SCD autopsy study, 943 presumed sudden […]
In patients with prior intracerebral hemorrhage, adding a single pill combining three low-dose antihypertensive agents to standard care significantly reduced recurrent stroke and major cardiovascular events compared with placebo. In this multinational, double-blind, randomized controlled trial of 1,670 clinically stable patients with baseline systolic blood pressure (BP) of 130–160 mm […]
In older adults, longer and more frequent daytime naps, particularly those occurring in the morning, were associated with a higher risk of all-cause mortality based on objective actigraphy measurements. In this prospective cohort study from the US Rush Memory and Aging Project, 1,338 community-dwelling adults (mean age 81.4 years, 76% […]
Anemia was associated with higher levels of Alzheimer disease (AD) blood biomarkers and a markedly increased long-term risk of dementia, with the highest risk observed when low hemoglobin coexisted with elevated neurodegenerative markers. In a population-based cohort from the Swedish National Study on Aging and Care in Kungsholmen, 2,282 dementia-free […]
Greater adherence to healthful plant-based diets was associated with a lower risk of Alzheimer disease and related dementias (ADRDs), whereas unhealthy plant-based diets were linked to increased risk, with dietary changes over time further influencing outcomes. In the prospective analysis of the US Multiethnic Cohort Study including over 92,000 diverse […]
In patients with established cardiovascular disease (CVD), calcium supplementation was associated with an increased risk of recurrent CVD events and related hospitalizations, particularly with calcium-only use and among men. In this large retrospective population-based study from Hong Kong, 17,720 matched patients receiving calcium supplements were compared with an equal number […]