Waist circumference (WC) and waist-to-hip ratio (WHR) identified important differences in cardiovascular disease (CVD) risk that were not captured by conventional BMI categories, suggesting that central adiposity can reclassify CVD risk across normal weight, overweight, and obesity and provide additional diagnostic and prognostic information. The US Cross-Cohort Collaboration study included […]
In a US longitudinal multi-omic study of 1,154 hospitalized patients with COVID-19 from the IMPACC cohort, significant reactivation of Herpesviridae and Anelloviridae was common during acute COVID-19, with virus-specific temporal patterns and associations with disease severity, host immune responses, and clinical outcomes. Chronic viral infections are ubiquitous in humans, and […]
The secondary analysis of a randomized clinical trial found that a low-fat vegan diet reduced dietary energy density by approximately 30%, leading to lower energy intake and greater weight loss without prescribed calorie restriction. The study included 244 adults with overweight who were randomly assigned to either an ad libitum […]
Maintaining optimal vascular health in midlife was associated with up to 12.6 additional years of life free from dementia between ages 55 and 95. The prospective analysis of 12,409 participants from the US Atherosclerosis Risk in Communities (ARIC) study followed for a median of 26.3 years, evaluated three major midlife […]