Long-term and intensive night shift work was associated with a significantly higher risk of cardiovascular–kidney–metabolic (CKM) disease in a large UK Biobank cohort, with the strongest effects seen among individuals who slept six hours or less per night. Among 96,365 participants followed through 2022, those with more than 20 years […]
Depression and anxiety were each associated with a higher risk of major adverse cardiac events, with the greatest risk observed when both conditions co-occurred, and these associations were partly mediated by heightened stress-related neural activity and downstream autonomic and inflammatory dysregulation. In more than 85,000 participants from the Mass General […]
Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]
Recent recommendations of the American College of Cardiology/American Heart Association Joint Committee emphasize that adults with congenital heart disease achieve better outcomes when managed at specialized adult congenital heart disease (ACHD) centers with multidisciplinary teams and close involvement of ACHD cardiologists, particularly for patients with moderate or complex anatomy or […]
In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]
Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]
In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]
In a population-based analysis of 371,032 UK Biobank participants, faster biological aging in males explained a substantial proportion of their higher cardiovascular disease (CVD) risk compared with females, accounting for about 60–68% of the excess risk across major CVD outcomes. Although males and females had similar chronological ages, males consistently […]
A systematic review of 17 randomized trials involving 66,337 adults found that reducing or modifying saturated fat intake offers little or no clinically meaningful benefit over five years for people at low cardiovascular risk, but may lead to important reductions in mortality and major cardiovascular events among those at high […]
Even moderate alcohol consumption was consistently linked to a higher risk of multiple cancers, with clear dose–response relationships showing that risk rises with greater frequency and quantity of drinking. In this systematic review of 62 U.S.-based studies, alcohol use was most strongly associated with increased risks of breast, colorectal, and […]