A French prospective cohort study concluded that better cardiovascular health (CVH) and the maintenance or improvement of CVH were associated with a lower risk of cancer. The study population included 13,933 participants (mainly Caucasian, mean age 45.3 years, 24% women). After a median follow-up of 24.8 years (19.4-24.9 years), 2,010 […]
A prospective US cohort study with up to 36 years of follow-up concluded that greater adherence to several healthy eating patterns was associated with a lower risk of total and cause-specific mortality. The study included 75 230 women (1984-2020, mean baseline age, 50.2 years) and 44 085 men (1986-2020, mean […]
A prospective histological cohort study in Japan revealed the association of periodontitis with atrial fibrosis. The study enrolled 76 patients with atrial fibrillation (AF, 55 with nonparoxysmal AF, 25 with mitral valve regurgitation, 18 with left atrial appendages [LAA] thrombus) who were scheduled to undergo LAA excision during cardiac surgery. […]
A prospective UK cohort study suggested that short sleep duration was associated with the onset of chronic disease and multimorbidity. The study included 7,864 (32.5% women) participants free of multimorbidity. Self-reported sleep duration was measured 6 times between 1985 and 2016. Incidence of multimorbidity was defined as having 2 or […]
A US multicenter, parallel-group, comparative-effectiveness clinical trial showed that when added to metformin, insulin glargine and glucagon-like peptide-1 receptor agonist liraglutide were significantly, albeit modestly, more effective in achieving and maintaining target glycated hemoglobin levels than sulfonylurea glimepiride or dipeptidyl peptidase 4 inhibitor sitagliptin in patients with type 2 diabetes […]
A French population based prospective cohort study suggests a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased cardiovascular disease (CVD) risk. The study included 103 388 participants of the web-based cohort (mean age 42.2 years, 79.8% female, 904 206 person years) from 2009 to […]
An individual participant data meta-analysis concluded that most (>90%) of all reports of muscle symptoms with statin therapy were not due to the statin, although statins did cause a small proportional increase in reports of muscle pain, largely during the first year of treatment. The analysis included 19 double-blind trials […]
A drug-target Mendelian randomization (MR) analysis indicated adverse neurocognitive effects related to statins but not proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition. Data were from a combined sample of ∼740,000 participants in predominantly European ancestry-based genome-wide association cohort studies. There was a neutral cognitive profile related to genetic PCSK9 inhibition, […]
A US randomized clinical trial suggested that early time-restricted eating (eTRE) was more effective for weight loss than eating over a window of 12 or more hours. A total of 90 obese participants (mean body mass index, 39.6; age, 43 years; 80% female) received weight-loss treatment (energy restriction [ER] of […]
A systematic review and network meta-analysis provided the most comprehensive data synthesis on pharmacological treatments for adults with insomnia. The study included 170 trials (36 interventions and 47 950 participants) in the systematic review and 154 double-blind, randomized controlled trials (30 interventions and 44 089 participants) for the network meta-analysis. Benzodiazepines, doxylamine, […]