Better mental wellbeing substantially reduces the risk of developing irritable bowel syndrome (IBS), with effects that are independent of genetic predisposition and partly mediated through lower depression and anxiety. In this prospective UK Biobank cohort of 75,842 IBS-free participants followed for 12.4 years, 1,400 incident IBS cases occurred, and higher […]
Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]
Clonal hematopoiesis of indeterminate potential (CHIP), particularly non-DNMT3A CHIP subtypes, is an independent risk factor for incident heart failure (HF) and may represent a novel therapeutic target. In a UK Biobank cohort of 417,616 adults (mean age, 56.1 years; 56.2% women) without prior HF or major comorbidities, 7,183 participants (1.7%) […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]
A systematic review and meta‐analysis suggests that influenza, SARS‐CoV‐2, HIV, hepatitis C virus, and herpes zoster are all associated with an increased risk of major cardiovascular events. The analysis included 155 studies, viral infections were consistently linked to higher rates of coronary heart disease (CHD) and stroke. HIV infection was […]
Ongoing peer-reviewed evidence supports the safety and effectiveness of vaccines against Covid-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. In a systematic review of 511 studies out of 17,263 identified references, Covid-19 mRNA vaccines targeting the XBB.1.5 subvariant showed pooled effectiveness against hospitalization of 46% from cohort […]
Findings of a UK clinical trial support the use of the Mediterranean diet (MD) as a first-line therapy for irritable bowel syndrome (IBS). A total of 139 adults with IBS (mean age 40.4 years; 80% women) from across the UK were randomized to follow either the MD (n = 68) […]
A systematic review and network meta-analysis evaluated the efficacy and safety of different exercise modalities for managing knee osteoarthritis, including aerobic, flexibility, mind-body, neuromotor, strengthening, and mixed exercises. A total of 217 randomized controlled trials involving 15,684 participants were analyzed, with outcomes assessed at short-term (4 weeks), mid-term (12 weeks), […]
The British Dietetic Association has developed the first comprehensive evidence-based dietary guidelines for the management of chronic constipation in adults. Four systematic reviews and meta-analyses encompassing 75 randomized controlled trials informed 59 recommendation statements, developed through the GRADE framework and Delphi consensus among a multidisciplinary Guideline Steering Committee. The recommendations […]
A combined observational and genetic study indicates that all levels of alcohol consumption may raise dementia risk, and reducing alcohol use disorder (AUD) could help lower dementia incidence at the population level. The study investigated the relationship between alcohol consumption and dementia using prospective cohort, case–control, and Mendelian randomization analyses […]