A prospective US population-based cohort study suggested that higher intake of butter was associated with increased mortality, while higher intake of plant-based oils was associated with lower mortality. Substituting butter with plant-based oils may prevent premature deaths. There were 221 054 adults with mean age at baseline of 36.1 ~ 56.3 […]
Cognitive Behavioral Therapy (CBT) has been shown to be effective in managing Irritable Bowel Syndrome (IBS) by addressing the connection between the gut and the brain. Following are some available programs: Mahana IBS (FDA-Approved): A clinically validated, prescription 3-month digital therapy program designed to reduce the severity of IBS symptoms. […]
A UK prospective study on diet and colorectal cancer found a marked positive association for alcohol, and a strong inverse association for calcium. The study examined associations of 97 dietary factors with colorectal cancer risk in 542,778 participants with 12,251 incident cases over 16.6 years, and conducted a targeted genetic […]
A UK device-based prospective study suggested that irregular sleep was associated with higher risk of major adverse cardiovascular events (MACE), regardless of whether individuals met sleep duration recommendations or not. The study included 72 269 individuals aged 40–79 years and followed for 7.8 years, without a previous history of MACE and […]
A study comparing UK adults conceived just before or after sugar rationing ended found that early-life sugar rationing reduced risk of type 2 diabetes (T2D) and high blood pressure (HBP). The sugar rationing ended in September 1953 restricted sugar intake to levels within current dietary guidelines, but consumption nearly doubled […]
An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]
A randomized, open-label, active parallel-controlled clinical trial showed that 2 nonconsecutive fasting days (with a daily energy intake of 500 kcal for women and 600 kcal for men) and 5 days of habitual intake per week and meal replacement diet (5:2 MR) achieved better glycemic control compared with metformin and […]
A prospective multicenter cohort study revealed that protocol-directed active surveillance is safe and effective for avoiding overtreatment and preventing undertreatment in patients with low-risk prostate cancer. The study included 2155 patients with favorable-risk prostate cancer and no prior treatment from 2008 to 2022 with a median follow-up of 7.2 years. […]
A US prospective population based cohort study suggested that higher ultra-processed food intake was associated with slightly increased all-cause mortality. The associations were mainly driven by meat/poultry/seafood based ready-to-eat products, sugar and artificially sweetened beverages, dairy based desserts, and ultra-processed breakfast foods. The study included 74 563 women (1984-2018) and 39 501 […]
The US Women’s Health Initiative (WHI) clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for […]