Monthly Archives: June 2024


No Mortality Benefit with Multivitamins Use

A US cohort study concludes that there is no mortality benefit of multivitamin use. The study included 390 124 participants (median age, 61.5 years; 55.4% male) without major chronic diseases from 3 prospective cohort studies. 40.9% of participants were never smokers, and 40.3% were college educated. Among daily multivitamin users, 49.3% […]


Significance of CVD Risk Factors in Childhood and Adulthood

A longitudinal cohort study suggested that childhood risk factors contributed both directly and indirectly to adult cardiovascular disease (CVD), and that intervening in the risk factors in childhood should be emphasized to reduce the risk of CVD later in life, especially body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). […]


A 5:2 Intermittent Fasting Meal Replacement Diet Beats Metformin and Empagliflozin in T2D

A randomized, open-label, active parallel-controlled clinical trial showed that 2 nonconsecutive fasting days (with a daily energy intake of 500 kcal for women and 600 kcal for men) and 5 days of habitual intake per week and meal replacement diet (5:2 MR) achieved better glycemic control compared with metformin and […]


Sleep Rhythm Disturbances May Be a Modifiable AD Risk Factor

A prospective population-based cohort study in the Netherlands suggests that sleep rhythm disturbances can precede amyloid-β (Aβ) deposition and may be a modifiable risk factor for Alzheimer disease (AD). From September 2018 to November 2021, 319 participants without dementia who underwent Aβ positron emission tomography (PET) were included with the […]


Community Based Intensive BP Control Effective and Safe

An open-cluster randomized clinical trial in China showed that a nonphysician community health care practitioner–led, multifaceted, intensive blood pressure (BP) intervention was effective and safe in younger and older individuals with high BP. From 2018 to 2023, 22 386 and 11 609 individuals (mean age 63.0 years, females 61.3%) 60 years and […]


Food Processing Crucial for CVD Risk

A UK prospective cohort study suggested that plant sourced non ultra-processed foods (UPF) linked to a lower risk of cardiovascular disease (CVD), while plant sourced UPF linked to a higher CVD risk. Data were from the UK Biobank participants (40–69 y, n = 126,842, median follow-up 9 y) who completed at least two 24-h […]


Sodium Intake Linked to Atopic Dermatitis

A cross-sectional study suggested that higher dietary sodium intake may be associated with a higher risk of atopic dermatitis (AD) diagnosis, active AD, and increasing AD severity. There were 215 832 participants (mean age, 56.52 years; 54.3% female) in the UK analytic cohort with 5% of AD patients. Mean (SD) estimated […]


Active Surveillance Safe and Effective for Low-Risk Prostate Cancer

A prospective multicenter cohort study revealed that protocol-directed active surveillance is safe and effective for avoiding overtreatment and preventing undertreatment in patients with low-risk prostate cancer. The study included 2155 patients with favorable-risk prostate cancer and no prior treatment from 2008 to 2022 with a median follow-up of 7.2 years. […]


Statins Still Beneficial in Old and Very Old Adults

A Chinese sequential target trial emulation comparing matched cohorts initiating versus not initiating statin therapy suggested benefits and safety of statin therapy in adults aged ≥75 years, even ≥85 years. The trial included persons 75 years or older who met indications for statin initiation from January 2008 to December 2015 […]