A cross-sectional study suggested that higher dietary sodium intake may be associated with a higher risk of atopic dermatitis (AD) diagnosis, active AD, and increasing AD severity. There were 215 832 participants (mean age, 56.52 years; 54.3% female) in the UK analytic cohort with 5% of AD patients. Mean (SD) estimated 24-hour urine sodium excretion was 3.01 (0.82) g per day using a single spot urine sample collected between March 31, 2006, and October 1, 2010. Multivariable logistic regression revealed that a 1-g increase in estimated 24-hour urine sodium excretion was associated with increased risk of AD (adjusted odds ratio [AOR], 1.11), active AD (AOR, 1.16), and increasing severity of AD (AOR, 1.11). In a US validation cohort of 13 014 participants, a 1 g per day higher dietary sodium intake estimated using dietary recall questionnaires was associated with a higher risk of current AD (AOR, 1.22). The findings are in line with other studies linking higher levels of dietary sodium intake with AD and suggest that restriction of dietary sodium intake may be a cost-effective and low-risk intervention for AD. Source: https://jamanetwork.com/
