A study comparing UK adults conceived just before or after sugar rationing ended found that early-life sugar rationing reduced risk of type 2 diabetes (T2D) and high blood pressure (HBP). The sugar rationing ended in September 1953 restricted sugar intake to levels within current dietary guidelines, but consumption nearly doubled […]
A Chinese nationwide case-crossover study revealed that lower temperatures were associated with higher risks of myocardial infarction (MI), and that the risk was more pronounced in MI with non-obstructive coronary arteries (MINOCA) than that of MI with obstructive coronary artery disease (MI-CAD). The study included 83 784 MINOCA patients and […]
A prospective cohort study suggests that personal exposure to brighter nights and darker days causes circadian disruption with poor health outcomes and increased mortality risk. Avoiding night light and seeking daylight may promote optimal health and longevity. From 2013 to 2016, 88,905 UK Biobank participants (mean age 62.4 years, 56.9% […]
Both clinician-rated and patient-reported outcomes suggested that mindfulness-based stress reduction (MBSR) was well-tolerated with comparable effectiveness to the first-line medication escitalopram for patients with anxiety disorders in a US randomized clinical trial. The trial included 276 participants (women 75%, men 25%; mean age 33 years; Asian 19%, Black 15%, Hispanic […]
The number of individuals with high blood pressure (BP) is increasing worldwide. The trajectory of BP control appears to be worsening in North America, some European countries, and elsewhere around the world. The risk for cardiovascular diseases (CVD) attributable to BP is on a continuous log-linear exposure variable scale, not […]
A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels among initially healthy U.S. women predicted incident cardiovascular events over a 30-year period. High-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels were measured at baseline in 27,939 healthy U.S. women with mean age of 54.7 […]
A French multicenter, open label, randomized, noninferiority trial suggested that interruption of long-term beta-blocker treatment was not found to be noninferior to a strategy of beta-blocker continuation in patients with a history of myocardial infarction (MI). A total of 3698 MI patients (mean age 63.5 years, 17.2% women) were randomized […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]