A US cohort study concludes that there is no mortality benefit of multivitamin use. The study included 390 124 participants (median age, 61.5 years; 55.4% male) without major chronic diseases from 3 prospective cohort studies. 40.9% of participants were never smokers, and 40.3% were college educated. Among daily multivitamin users, 49.3% […]
A cross-sectional study suggested that higher dietary sodium intake may be associated with a higher risk of atopic dermatitis (AD) diagnosis, active AD, and increasing AD severity. There were 215 832 participants (mean age, 56.52 years; 54.3% female) in the UK analytic cohort with 5% of AD patients. Mean (SD) estimated […]
A US prospective population based cohort study suggested that higher ultra-processed food intake was associated with slightly increased all-cause mortality. The associations were mainly driven by meat/poultry/seafood based ready-to-eat products, sugar and artificially sweetened beverages, dairy based desserts, and ultra-processed breakfast foods. The study included 74 563 women (1984-2018) and 39 501 […]
The US Women’s Health Initiative (WHI) clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for […]
Data from a population-based cohort study in the Netherlands suggested that sarcopenic obesity (SO) may be associated with worse survival, and screening for muscle function may help for early identification and prevent premature death among older people. From March 1, 2009, to June 1, 2014, 5888 participants (mean age, 69.5 […]
A Mendelian randomization (MR) analysis did not find sufficient evidence to support a causal relationship between red/processed meat consumption and cardiovascular disease (CAD), hypertension, stroke, and type 2 diabetes (T2D). The analysis used data of publicly published genome-wide association studies. The inverse-variance weighted analyses revealed no causal association between the […]
The post hoc analysis of postintervention follow-up of calcium and vitamin D (CaD) supplements suggested reduced cancer mortality and increased cardiovascular disease (CVD) mortality. The multicenter trial across the US included 36 282 postmenopausal women randomized 1:1 to 1000 mg of calcium carbonate (400 mg of elemental calcium) with 400 IU […]
A prospective dose–response analysis of total daily steps with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels revealed that any number of daily steps above 2200 steps/day was associated with lower mortality and incident CVD risk, with 9000–10 500 steps/day being associated with the lowest mortality risk independent […]
A UK cohort study suggested that irregular sleep may represent a novel dementia risk factor. A random selection of 88,094 individuals (mean age 62 years, 56% women, and median sleep regularity index [SRI] 60) from a UK cohort was done between February 2013 and December 2015. The SRI was calculated […]
A US randomized clinical trial of healthy adult identical twin pairs showed that a healthy plant-based diet offers a significant protective cardiometabolic advantage compared with a healthy omnivorous diet. The open-label, parallel, dietary randomized clinical trial enrolled 22 pairs of twins (N = 44, 34 female; mean age, 39.6 years; mean body […]