A pooled analysis of lifestyle intervention trials suggested that adopting a healthy lifestyle can confer metabolic benefits beyond weight loss (WL) alone. The study investigated how individual responses to long-term lifestyle interventions for WL affect cardiometabolic risk by pooling data from three long-term lifestyle WL-intervention trials with adherence rates of […]
A recent article explored the science and skepticism surrounding seed oils. These oils—extracted from sources such as soy, canola, sunflower, and corn—are rich in unsaturated fats, particularly polyunsaturated fats (PUFAs) like omega-6 linoleic acid. A substantial body of evidence supports the health benefits of replacing saturated fats with PUFAs. However, […]
A study shows that eating a lot of highly processed foods is likely causing a significant number of early deaths around the world. First, a dose–response meta-analysis of observational cohort studies was performed to assess the association between ultraprocessed food consumption and all-cause mortality. Then, an estimation was made for […]
A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater weight loss than daily caloric restriction (DCR) in adults with overweight or obesity. The study included 165 participants (mean age: 42; mean BMI: 34.1 kg/m²; 73.9% female), randomly assigned to either 4:3 IMF (n=84) or […]
A prospective US population-based cohort study suggested that higher intake of butter was associated with increased mortality, while higher intake of plant-based oils was associated with lower mortality. Substituting butter with plant-based oils may prevent premature deaths. There were 221 054 adults with mean age at baseline of 36.1 ~ 56.3 […]
A UK prospective study on diet and colorectal cancer found a marked positive association for alcohol, and a strong inverse association for calcium. The study examined associations of 97 dietary factors with colorectal cancer risk in 542,778 participants with 12,251 incident cases over 16.6 years, and conducted a targeted genetic […]
A UK device-based prospective study suggested that irregular sleep was associated with higher risk of major adverse cardiovascular events (MACE), regardless of whether individuals met sleep duration recommendations or not. The study included 72 269 individuals aged 40–79 years and followed for 7.8 years, without a previous history of MACE and […]
A prospective cohort study suggests that personal exposure to brighter nights and darker days causes circadian disruption with poor health outcomes and increased mortality risk. Avoiding night light and seeking daylight may promote optimal health and longevity. From 2013 to 2016, 88,905 UK Biobank participants (mean age 62.4 years, 56.9% […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]