A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels among initially healthy U.S. women predicted incident cardiovascular events over a 30-year period. High-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels were measured at baseline in 27,939 healthy U.S. women with mean age of 54.7 […]
A French multicenter, open label, randomized, noninferiority trial suggested that interruption of long-term beta-blocker treatment was not found to be noninferior to a strategy of beta-blocker continuation in patients with a history of myocardial infarction (MI). A total of 3698 MI patients (mean age 63.5 years, 17.2% women) were randomized […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]
A multilipid score (MLS), reflecting the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations, was associated with significantly lower risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). The MLS was based on lipidomics data from a randomized controlled dietary intervention trial, replacing specific […]
An observational analysis found that many of older adults with high blood pressure (BP) could be reversed without the intervention of drug treatment in the first few years after diagnosis, and the remission was associated with a lower risk of cardiovascular disease (CVD). The analysis included 2760 participants aged 33–99 […]
A Japanese nationwide cohort study suggested that a diverse array of electrocardiogram (ECG) abnormalities was associated with an increased mortality and cardiovascular disease (CVD). The study included data of 3 698 429 working individuals (mean age, 47.1 years; 66.6% male) from April 1, 2015, to March 31, 2022, 16.8% had 1 minor […]
A longitudinal cohort study suggested that childhood risk factors contributed both directly and indirectly to adult cardiovascular disease (CVD), and that intervening in the risk factors in childhood should be emphasized to reduce the risk of CVD later in life, especially body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). […]
An open-cluster randomized clinical trial in China showed that a nonphysician community health care practitioner–led, multifaceted, intensive blood pressure (BP) intervention was effective and safe in younger and older individuals with high BP. From 2018 to 2023, 22 386 and 11 609 individuals (mean age 63.0 years, females 61.3%) 60 years and […]
A UK prospective cohort study suggested that plant sourced non ultra-processed foods (UPF) linked to a lower risk of cardiovascular disease (CVD), while plant sourced UPF linked to a higher CVD risk. Data were from the UK Biobank participants (40–69 y, n = 126,842, median follow-up 9 y) who completed at least two 24-h […]