Endotyping-informed therapy guided by adenosine stress cardiovascular MRI revised diagnoses in over half of patients with chest pain and unobstructed coronary arteries and significantly improved angina and quality of life at 12 months. In this prospective, multicenter, randomized controlled trial of 250 patients (mean age 63.3 years; 50.4% female) in […]
In patients with ST-segment elevation myocardial infarction (STEMI), early subcutaneous administration of zalunfiban significantly improved coronary artery patency and reduced the risk of adverse 30-day clinical outcomes without increasing severe bleeding. In an international, double-blind, placebo-controlled trial of 2,467 patients randomly assigned to receive zalunfiban (0.11 mg/kg or 0.13 mg/kg) […]
Clonal hematopoiesis of indeterminate potential (CHIP), particularly non-DNMT3A CHIP subtypes, is an independent risk factor for incident heart failure (HF) and may represent a novel therapeutic target. In a UK Biobank cohort of 417,616 adults (mean age, 56.1 years; 56.2% women) without prior HF or major comorbidities, 7,183 participants (1.7%) […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]
Intracoronary infusion of Wharton’s jelly–derived mesenchymal stem cells after acute myocardial infarction (AMI) significantly reduced the risk of developing heart failure (HF) and related adverse cardiovascular events, suggesting its potential as a valuable adjunctive therapy. In a Iranian phase 3 randomized clinical trial involving 420 patients with a first ST-segment […]
Higher physical activity may slow cognitive and functional decline in older adults at risk for Alzheimer’s disease (AD) by reducing tau accumulation rather than amyloid burden. In a study of cognitively unimpaired older adults with pedometer-measured step counts, greater physical activity was linked to slower decline among those with elevated […]
A systematic review and meta‐analysis suggests that influenza, SARS‐CoV‐2, HIV, hepatitis C virus, and herpes zoster are all associated with an increased risk of major cardiovascular events. The analysis included 155 studies, viral infections were consistently linked to higher rates of coronary heart disease (CHD) and stroke. HIV infection was […]
Ongoing peer-reviewed evidence supports the safety and effectiveness of vaccines against Covid-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. In a systematic review of 511 studies out of 17,263 identified references, Covid-19 mRNA vaccines targeting the XBB.1.5 subvariant showed pooled effectiveness against hospitalization of 46% from cohort […]
A placebo-controlled, n-of-1 study suggested that coronary collateralization may lessen the intensity of ischemic chest pain. The study included 51 participants with stable single-vessel coronary artery disease and angina. After discontinuing antianginal medications, participants recorded daily angina using a smartphone app for 14 days before undergoing invasive pressure wire studies […]
Findings of a UK clinical trial support the use of the Mediterranean diet (MD) as a first-line therapy for irritable bowel syndrome (IBS). A total of 139 adults with IBS (mean age 40.4 years; 80% women) from across the UK were randomized to follow either the MD (n = 68) […]