A Mendelian randomization (MR) analysis did not find sufficient evidence to support a causal relationship between red/processed meat consumption and cardiovascular disease (CAD), hypertension, stroke, and type 2 diabetes (T2D). The analysis used data of publicly published genome-wide association studies. The inverse-variance weighted analyses revealed no causal association between the […]
The post hoc analysis of postintervention follow-up of calcium and vitamin D (CaD) supplements suggested reduced cancer mortality and increased cardiovascular disease (CVD) mortality. The multicenter trial across the US included 36 282 postmenopausal women randomized 1:1 to 1000 mg of calcium carbonate (400 mg of elemental calcium) with 400 IU […]
A prospective dose–response analysis of total daily steps with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels revealed that any number of daily steps above 2200 steps/day was associated with lower mortality and incident CVD risk, with 9000–10 500 steps/day being associated with the lowest mortality risk independent […]
A UK cohort study suggested that irregular sleep may represent a novel dementia risk factor. A random selection of 88,094 individuals (mean age 62 years, 56% women, and median sleep regularity index [SRI] 60) from a UK cohort was done between February 2013 and December 2015. The SRI was calculated […]
A US randomized clinical trial of healthy adult identical twin pairs showed that a healthy plant-based diet offers a significant protective cardiometabolic advantage compared with a healthy omnivorous diet. The open-label, parallel, dietary randomized clinical trial enrolled 22 pairs of twins (N = 44, 34 female; mean age, 39.6 years; mean body […]
A UK prospective cohort analysis suggested that both functional (subjective) and structural (objective) measures of social connection were independently associated with all-cause and cardiovascular disease (CVD) mortality. The analysis included 458,146 participants with a median of 12.6 years follow-up, 33,135 (7.2%) deaths, including 5112 (1.1%) CVD deaths. Friends/family visit frequencies < monthly were […]
A US randomized clinical trial found that time-restricted eating (TRE) without calorie counting was effective for weight loss and lowering of HbA1c levels in T2D adults. Between January 25, 2022, and April 1, 2023, 75 adults (mean age of 55, 71% women) with T2D were randomized to 1 of 3 […]
A UK pragmatic, superiority, open label, randomized controlled trial of sleep restriction therapy (SRT) versus sleep hygiene concluded that brief primary care nurse delivered SRT is both clinically effective and cost-effective in treating insomnia disorder and improving other aspects of mental health and functioning. A total of 642 participants (mean […]
The analysis of a UK cohort study suggests that a weekend warrior pattern of physical activity was associated with similarly lower risks of cardiovascular diseases (CVD) to regular activity. A total of 89 573 individuals (mean age, 62 years; 56% women) who underwent accelerometry were included. When stratified at the threshold […]
A 1-year US randomized controlled trial concluded that time-restricted eating (TRE) without calorie counting is effective in weight loss, on par with calorie restriction (CR). Ninety obese participants were randomly assigned to 8-hour TRE (eating between noon and 8:00 p.m. only, without calorie counting), CR (25% energy restriction daily), or control […]