A longitudinal cohort study suggested that childhood risk factors contributed both directly and indirectly to adult cardiovascular disease (CVD), and that intervening in the risk factors in childhood should be emphasized to reduce the risk of CVD later in life, especially body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). […]
An open-cluster randomized clinical trial in China showed that a nonphysician community health care practitioner–led, multifaceted, intensive blood pressure (BP) intervention was effective and safe in younger and older individuals with high BP. From 2018 to 2023, 22 386 and 11 609 individuals (mean age 63.0 years, females 61.3%) 60 years and […]
A UK prospective cohort study suggested that plant sourced non ultra-processed foods (UPF) linked to a lower risk of cardiovascular disease (CVD), while plant sourced UPF linked to a higher CVD risk. Data were from the UK Biobank participants (40–69 y, n = 126,842, median follow-up 9 y) who completed at least two 24-h […]
A Chinese sequential target trial emulation comparing matched cohorts initiating versus not initiating statin therapy suggested benefits and safety of statin therapy in adults aged ≥75 years, even ≥85 years. The trial included persons 75 years or older who met indications for statin initiation from January 2008 to December 2015 […]
A Chinese cohort study suggested a causal effect of gut microbiota on non-HDL-c and identified 3-indolepropionic acid and N-methyltryptamine as key effectors of gut microbiota to the variation of non-high-density lipoprotein cholesterol (non-HDL-c). The study included a total of 1361 community-dwelling participants without major diseases and free of antibiotics and lipid-lowering […]
The US guideline for the management of hypertrophic cardiomyopathy (HCM) have been updated. The top 10 take-home messages are: Shared decision-making is essential to provide the best clinical care. Referral to multidisciplinary HCM centers with appropriate expertise can be important to optimizing care for patients with HCM. Careful ascertainment of […]
A single-stage common-variant genome-wide association study (GWAS) of blood pressure (BP) in European-ancestry adults improved BP polygenic risk scores (PRS) and provided additional insights into the genetic contribution of BP. The study identified 113 novel loci, reporting a total of 2,103 independent genetic signals in 1,028,980 European individuals from the […]
The US Women’s Health Initiative (WHI) clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for […]
A prospective Chinese Mendelian randomization study revealed that participants with higher body mass index (BMI) but lower waist circumference (WC) had the lowest mortality risk among the oldest-old. The study enrolled 5306 community-based oldest-old (mean age 90.6 years) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide […]
A US cohort study suggested that physical activity (PA) appears to reduce cardiovascular disease (CVD) risk in part by acting through the brain’s stress-related activity. The study included a total of 50,359 adults (median age 60 years; 40.1% male). Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical […]