Studies suggested that terminal breakdown products of excess niacin (vitamin B3 or nicotinic acid) are associated with residual cardiovascular disease (CVD) risk and provided a possible explanation for the ‘niacin paradox’—the observation that the LDL lowering induced by niacin fails to achieve the expected reduction in CVD risks. Untargeted metabolomics […]
The analysis of a UK cohort study suggests that a weekend warrior pattern of physical activity was associated with similarly lower risks of cardiovascular diseases (CVD) to regular activity. A total of 89 573 individuals (mean age, 62 years; 56% women) who underwent accelerometry were included. When stratified at the threshold […]
A cross-sectional analysis suggested that a multivariable model of clinical and genetic risk factors explains only 36% of the likelihood of family history of heart disease (FHHD), with most of the risk of a FHHD unexplained. The analysis included 166,714 UK Biobank participants with 43.2% reported a FHHD. In the […]
A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]
A collaborative analysis of 3 multinational trials suggested that inflammatory risk was a stronger predictor of cardiovascular disease (CVD) events, CVD death, and all-cause death than residual cholesterol risk in statin users. The analysis included 31245 statin users with/or at high risk of atherosclerotic disease. The observed ranges for baseline […]
A French prospective cohort study concluded that better cardiovascular health (CVH) and the maintenance or improvement of CVH were associated with a lower risk of cancer. The study population included 13,933 participants (mainly Caucasian, mean age 45.3 years, 24% women). After a median follow-up of 24.8 years (19.4-24.9 years), 2,010 […]
A prospective UK cohort study suggested that higher free sugar intake was associated with higher cardiovascular disease (CVD) incidence and higher triglyceride concentrations within all lipoproteins. Higher fiber intake and replacement of refined grain starch and free sugars with wholegrain starch and non-free sugars, respectively, may be protective for incident […]
A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]
A global study concluded that exposure to extreme hot and cold temperatures was associated with a higher mortality from multiple common cardiovascular diseases (CVD). The study used data of daily counts of specific CVD death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 […]
A systematic review and meta-analysis of randomized controlled intervention trials of micronutrients on cardiovascular disease (CVD) and clinical events concluded that some but not all micronutrients may be beneficial. The analysis identified a total of 884 randomized controlled intervention trials evaluating 27 types of micronutrients among 883,627 participants (4,895,544 person-years). […]