A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater weight loss than daily caloric restriction (DCR) in adults with overweight or obesity. The study included 165 participants (mean age: 42; mean BMI: 34.1 kg/m²; 73.9% female), randomly assigned to either 4:3 IMF (n=84) or […]
A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor agonists (GLP1-RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) were associated with reduced rates of 3-point major adverse cardiovascular events (3P-MACE) and hospitalization for heart failure (HHF) compared to dipeptidyl peptidase 4 inhibitors (DPP-4is). Compared to […]
A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty evidence that non-steroidal anti-inflammatory drugs (NSAIDs) are efficacious for acute low back pain, and that exercise, spinal manipulative therapy, taping, antidepressants, and transient receptor potential vanilloid 1 (TRPV1) agonists are efficacious for chronic low back […]
A US cohort study indicated that statin use may reduce the risks of hepatocellular carcinoma (HCC) and progression of chronic liver disease (CLD). The study included 16 501 CLD patients (mean age, 59.7 years, females 40.9%), with 3610 statin users and 12 891 nonusers. Compared with nonusers, statin users exhibited a significantly […]
A prospective US population-based cohort study suggested that higher intake of butter was associated with increased mortality, while higher intake of plant-based oils was associated with lower mortality. Substituting butter with plant-based oils may prevent premature deaths. There were 221 054 adults with mean age at baseline of 36.1 ~ 56.3 […]
Cognitive Behavioral Therapy (CBT) has been shown to be effective in managing Irritable Bowel Syndrome (IBS) by addressing the connection between the gut and the brain. Following are some available programs: Mahana IBS (FDA-Approved): A clinically validated, prescription 3-month digital therapy program designed to reduce the severity of IBS symptoms. […]
A UK prospective study on diet and colorectal cancer found a marked positive association for alcohol, and a strong inverse association for calcium. The study examined associations of 97 dietary factors with colorectal cancer risk in 542,778 participants with 12,251 incident cases over 16.6 years, and conducted a targeted genetic […]
A UK device-based prospective study suggested that irregular sleep was associated with higher risk of major adverse cardiovascular events (MACE), regardless of whether individuals met sleep duration recommendations or not. The study included 72 269 individuals aged 40–79 years and followed for 7.8 years, without a previous history of MACE and […]
A study comparing UK adults conceived just before or after sugar rationing ended found that early-life sugar rationing reduced risk of type 2 diabetes (T2D) and high blood pressure (HBP). The sugar rationing ended in September 1953 restricted sugar intake to levels within current dietary guidelines, but consumption nearly doubled […]
An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]